| pubmed-article:18765477 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18765477 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:18765477 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:18765477 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:18765477 | lifeskim:mentions | umls-concept:C0022646 | lld:lifeskim |
| pubmed-article:18765477 | lifeskim:mentions | umls-concept:C0034790 | lld:lifeskim |
| pubmed-article:18765477 | lifeskim:mentions | umls-concept:C0108779 | lld:lifeskim |
| pubmed-article:18765477 | lifeskim:mentions | umls-concept:C0205307 | lld:lifeskim |
| pubmed-article:18765477 | lifeskim:mentions | umls-concept:C2700400 | lld:lifeskim |
| pubmed-article:18765477 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:18765477 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:18765477 | pubmed:dateCreated | 2008-11-21 | lld:pubmed |
| pubmed-article:18765477 | pubmed:abstractText | Healthy liver, intestine, lung, and skin harbor resident lymphocytes with conventional and unconventional phenotypes. Lymphocytes also have been detected in healthy mice kidneys; however, these cells have not been well studied and have been largely overlooked. To better characterize the intra-renal lymphocytes, we extensively perfused C57BL/6J mice with PBS and then isolated mononuclear cells for flow cytometry analysis. We observed T cells, B cells, and NK cells in normal mice kidneys after extensive perfusion. Approximately 50% of kidney T lymphocytes expressed intermediate levels of CD3 (CD3int T cells). Similar to liver and lung, a high percentage of unconventional CD3+CD4(-)CD8(-) double-negative T cells was observed in normal mice kidneys, from which 11% expressed B220 antigen. Unlike the spleen and blood, the classic CD4+ and CD8+ T lymphocytes in the kidney had a high proportion of activated CD69+ and effector/memory CD44- CD62L ligand phenotypes. Also, a small percentage of CD4+CD25+forkhead box p3+ and NKT cells was observed in perfused and exanguinated kidneys. In addition, a distinct TCR repertoire was found on intra-renal conventional and unconventional T cells compared with those from the spleen. Finally, after 24 h of renal ischemia reperfusion injury (IRI), increased production of cytokines IFN-gamma and TNF-alpha by CD4+ and CD8+ T cells, isolated from perfused kidneys, was observed. These data suggest that some of these cells harbored in the kidney could be implicated in the immune response of the IRI pathogenic process. | lld:pubmed |
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| pubmed-article:18765477 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18765477 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18765477 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:18765477 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18765477 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:18765477 | pubmed:issn | 0741-5400 | lld:pubmed |
| pubmed-article:18765477 | pubmed:author | pubmed-author:ColvinRobert... | lld:pubmed |
| pubmed-article:18765477 | pubmed:author | pubmed-author:RabbHamidH | lld:pubmed |
| pubmed-article:18765477 | pubmed:author | pubmed-author:RacusenLorrai... | lld:pubmed |
| pubmed-article:18765477 | pubmed:author | pubmed-author:SoloskiMark... | lld:pubmed |
| pubmed-article:18765477 | pubmed:author | pubmed-author:AsconDolores... | lld:pubmed |
| pubmed-article:18765477 | pubmed:author | pubmed-author:Lopez-Briones... | lld:pubmed |
| pubmed-article:18765477 | pubmed:author | pubmed-author:AsconMiguelM | lld:pubmed |
| pubmed-article:18765477 | pubmed:author | pubmed-author:SatputeShaile... | lld:pubmed |
| pubmed-article:18765477 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18765477 | pubmed:volume | 84 | lld:pubmed |
| pubmed-article:18765477 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18765477 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18765477 | pubmed:pagination | 1400-9 | lld:pubmed |
| pubmed-article:18765477 | pubmed:dateRevised | 2010-9-21 | lld:pubmed |
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