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pubmed-article:18762934pubmed:dateCreated2008-12-18lld:pubmed
pubmed-article:18762934pubmed:abstractTextThis paper assesses the design of clinical studies used in the process of regulatory approval, focusing on how add-on studies affect regulatory decisions.lld:pubmed
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pubmed-article:18762934pubmed:articleTitleLimits of add-on trials: antirheumatic drugs.lld:pubmed
pubmed-article:18762934pubmed:affiliationLaboratory of Regulatory Policies, Mario Negri Institute for Pharmacological Research, Via Giuseppe La Masa 19, 20156 Milan, Italy.lld:pubmed
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