| pubmed-article:18762712 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18762712 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:18762712 | lifeskim:mentions | umls-concept:C0205753 | lld:lifeskim |
| pubmed-article:18762712 | lifeskim:mentions | umls-concept:C1420101 | lld:lifeskim |
| pubmed-article:18762712 | lifeskim:mentions | umls-concept:C1948023 | lld:lifeskim |
| pubmed-article:18762712 | lifeskim:mentions | umls-concept:C1948027 | lld:lifeskim |
| pubmed-article:18762712 | lifeskim:mentions | umls-concept:C0597484 | lld:lifeskim |
| pubmed-article:18762712 | lifeskim:mentions | umls-concept:C1710236 | lld:lifeskim |
| pubmed-article:18762712 | lifeskim:mentions | umls-concept:C0205227 | lld:lifeskim |
| pubmed-article:18762712 | lifeskim:mentions | umls-concept:C0070351 | lld:lifeskim |
| pubmed-article:18762712 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:18762712 | pubmed:dateCreated | 2008-9-2 | lld:pubmed |
| pubmed-article:18762712 | pubmed:abstractText | We have recently identified a Na+/Cl--coupled transport system in mammalian cells for endogenous and synthetic opioid peptides. This transport system does not transport dipeptides/tripeptides, but is stimulated by these small peptides. Here we investigated the influence of L-kyotorphin (L-Tyr-L-Arg), an endogenous dipeptide with opioid activity, on this transport system. The activity of the transport system, measured in SK-N-SH cells (a human neuronal cell line) with deltorphin II as a model substrate, was stimulated approximately 2.5-fold by L-kyotorphin, with half-maximal stimulation occurring at approximately 100 microM. The stimulation was associated primarily with an increase in the affinity for deltorphin II. The stimulation caused by L-kyotorphin was stereospecific; L-Tyr-D-Arg (D-kyotorphin) had minimal effect. The influence of L-kyotorphin was observed also in a different cell line which expressed the opioid peptide transport system. While L-kyotorphin is a stimulator of opioid peptide transport, it is a transportable substrate for the H+-coupled peptide transporter PEPT2, which is expressed widely in the brain. Since the activity of the opioid peptide transport system is modulated by extracellular L-kyotorphin and since PEPT2 is an important determinant of extracellular L-kyotorphin in the brain, the expression/activity of PEPT2 may be a critical factor in the modulation of opioidergic neurotransmission in vivo. | lld:pubmed |
| pubmed-article:18762712 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18762712 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18762712 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18762712 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18762712 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18762712 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18762712 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18762712 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18762712 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18762712 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18762712 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18762712 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18762712 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18762712 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18762712 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18762712 | pubmed:issn | 1880-0920 | lld:pubmed |
| pubmed-article:18762712 | pubmed:author | pubmed-author:MiyauchiSeiji... | lld:pubmed |
| pubmed-article:18762712 | pubmed:author | pubmed-author:GanapathyVadi... | lld:pubmed |
| pubmed-article:18762712 | pubmed:author | pubmed-author:PrasadPuttur... | lld:pubmed |
| pubmed-article:18762712 | pubmed:author | pubmed-author:ThakkarSantos... | lld:pubmed |
| pubmed-article:18762712 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18762712 | pubmed:volume | 23 | lld:pubmed |
| pubmed-article:18762712 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18762712 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18762712 | pubmed:pagination | 254-62 | lld:pubmed |
| pubmed-article:18762712 | pubmed:meshHeading | pubmed-meshheading:18762712... | lld:pubmed |
| pubmed-article:18762712 | pubmed:meshHeading | pubmed-meshheading:18762712... | lld:pubmed |
| pubmed-article:18762712 | pubmed:meshHeading | pubmed-meshheading:18762712... | lld:pubmed |
| pubmed-article:18762712 | pubmed:meshHeading | pubmed-meshheading:18762712... | lld:pubmed |
| pubmed-article:18762712 | pubmed:meshHeading | pubmed-meshheading:18762712... | lld:pubmed |
| pubmed-article:18762712 | pubmed:meshHeading | pubmed-meshheading:18762712... | lld:pubmed |
| pubmed-article:18762712 | pubmed:meshHeading | pubmed-meshheading:18762712... | lld:pubmed |
| pubmed-article:18762712 | pubmed:meshHeading | pubmed-meshheading:18762712... | lld:pubmed |
| pubmed-article:18762712 | pubmed:meshHeading | pubmed-meshheading:18762712... | lld:pubmed |
| pubmed-article:18762712 | pubmed:meshHeading | pubmed-meshheading:18762712... | lld:pubmed |
| pubmed-article:18762712 | pubmed:meshHeading | pubmed-meshheading:18762712... | lld:pubmed |
| pubmed-article:18762712 | pubmed:meshHeading | pubmed-meshheading:18762712... | lld:pubmed |
| pubmed-article:18762712 | pubmed:meshHeading | pubmed-meshheading:18762712... | lld:pubmed |
| pubmed-article:18762712 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18762712 | pubmed:articleTitle | Stimulation of Na+/Cl--coupled opioid peptide transport system in SK-N-SH cells by L-kyotorphin, an endogenous substrate for H+-coupled peptide transporter PEPT2. | lld:pubmed |
| pubmed-article:18762712 | pubmed:affiliation | Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, GA 30912, USA. | lld:pubmed |
| pubmed-article:18762712 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18762712 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| entrez-gene:6565 | entrezgene:pubmed | pubmed-article:18762712 | lld:entrezgene |
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