| pubmed-article:18762581 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18762581 | lifeskim:mentions | umls-concept:C0031715 | lld:lifeskim |
| pubmed-article:18762581 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:18762581 | lifeskim:mentions | umls-concept:C1416917 | lld:lifeskim |
| pubmed-article:18762581 | lifeskim:mentions | umls-concept:C1427462 | lld:lifeskim |
| pubmed-article:18762581 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:18762581 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:18762581 | lifeskim:mentions | umls-concept:C1998811 | lld:lifeskim |
| pubmed-article:18762581 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:18762581 | pubmed:dateCreated | 2008-9-9 | lld:pubmed |
| pubmed-article:18762581 | pubmed:abstractText | The low-density lipoprotein receptor-related proteins 5 and 6 (LRP5/6) are coreceptors for Frizzled and transmit signals from the plasma membrane to the cytosol. However, the mechanism for LRP5/6 signal transmission remains undefined. Here, we identify cytoplasmic activation/proliferation-associated protein 2 (Caprin-2) as a LRP5/6-binding protein. Our data show that Caprin-2 stabilizes cytosolic beta-catenin and enhances lymphoid enhancer-binding factor 1/T cell factor-dependent reporter gene activity as well as the expression of Wnt target genes in mammalian cells. Morpholino-mediated knockdown of Caprin-2 in zebrafish embryos inhibits Wnt/beta-catenin signaling and results in a dorsalized phenotype. Moreover, Caprin-2 facilitates LRP5/6 phosphorylation by glycogen synthase kinase 3, and thus enhances the interaction between Axin and LRP5/6. Therefore, Caprin-2 promotes activation of the canonical Wnt signaling pathway by regulating LRP5/6 phosphorylation. | lld:pubmed |
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| pubmed-article:18762581 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18762581 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18762581 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18762581 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18762581 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18762581 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18762581 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18762581 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18762581 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18762581 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18762581 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18762581 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18762581 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18762581 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18762581 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18762581 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18762581 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18762581 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18762581 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18762581 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18762581 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18762581 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18762581 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18762581 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18762581 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18762581 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18762581 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18762581 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18762581 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18762581 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18762581 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18762581 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18762581 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18762581 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18762581 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18762581 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18762581 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18762581 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18762581 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18762581 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18762581 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18762581 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18762581 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18762581 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18762581 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18762581 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:18762581 | pubmed:issn | 1540-8140 | lld:pubmed |
| pubmed-article:18762581 | pubmed:author | pubmed-author:JooFF | lld:pubmed |
| pubmed-article:18762581 | pubmed:author | pubmed-author:FordF SFS | lld:pubmed |
| pubmed-article:18762581 | pubmed:author | pubmed-author:ChenLiL | lld:pubmed |
| pubmed-article:18762581 | pubmed:author | pubmed-author:ZengRongR | lld:pubmed |
| pubmed-article:18762581 | pubmed:author | pubmed-author:ChenTingT | lld:pubmed |
| pubmed-article:18762581 | pubmed:author | pubmed-author:XiYingY | lld:pubmed |
| pubmed-article:18762581 | pubmed:author | pubmed-author:LiYi-pingYP | lld:pubmed |
| pubmed-article:18762581 | pubmed:author | pubmed-author:WangJi-yongJY | lld:pubmed |
| pubmed-article:18762581 | pubmed:author | pubmed-author:TaoDong-leiDL | lld:pubmed |
| pubmed-article:18762581 | pubmed:author | pubmed-author:WuZhi-LiZL | lld:pubmed |
| pubmed-article:18762581 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18762581 | pubmed:day | 8 | lld:pubmed |
| pubmed-article:18762581 | pubmed:volume | 182 | lld:pubmed |
| pubmed-article:18762581 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18762581 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18762581 | pubmed:pagination | 865-72 | lld:pubmed |
| pubmed-article:18762581 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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