| pubmed-article:1876236 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1876236 | lifeskim:mentions | umls-concept:C0007452 | lld:lifeskim |
| pubmed-article:1876236 | lifeskim:mentions | umls-concept:C0032005 | lld:lifeskim |
| pubmed-article:1876236 | lifeskim:mentions | umls-concept:C0037663 | lld:lifeskim |
| pubmed-article:1876236 | lifeskim:mentions | umls-concept:C0015744 | lld:lifeskim |
| pubmed-article:1876236 | lifeskim:mentions | umls-concept:C0439851 | lld:lifeskim |
| pubmed-article:1876236 | lifeskim:mentions | umls-concept:C2911691 | lld:lifeskim |
| pubmed-article:1876236 | lifeskim:mentions | umls-concept:C1154417 | lld:lifeskim |
| pubmed-article:1876236 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:1876236 | lifeskim:mentions | umls-concept:C1552596 | lld:lifeskim |
| pubmed-article:1876236 | lifeskim:mentions | umls-concept:C1947931 | lld:lifeskim |
| pubmed-article:1876236 | lifeskim:mentions | umls-concept:C0205228 | lld:lifeskim |
| pubmed-article:1876236 | lifeskim:mentions | umls-concept:C0332120 | lld:lifeskim |
| pubmed-article:1876236 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:1876236 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:1876236 | pubmed:dateCreated | 1991-9-24 | lld:pubmed |
| pubmed-article:1876236 | pubmed:abstractText | To test the hypothesis that one aspect of growth hormone (GH) regulation involves a direct effect of GH on its own secretion at the level of the pituitary, we evaluated the effects of human GH on basal and GH-releasing factor (GRF)-induced GH secretion in rat and bovine pituitary cell cultures. Both 4 h (acute) and 24 h (chronic) exposure of bovine pituitary cells to exogenous human GH significantly (p less than 0.001) reduced GH secretion. Acute treatment resulted in a decrease in GH secretion from 579 +/- 24 to 500 +/- 17 ng/ml 4 h (mean +/- SEM, n = 24) while chronic treatment resulted in a GH decrease from 595 +/- 21 to 483 +/- 17 ng/ml/4 h. In contrast, human GH treatment of rat somatotropes had no effect on basal GH secretion. GRF-stimulated GH secretion was not affected by either acute or chronic GH exposure in either species. These results demonstrate that there are species-specific differences in the ability of GH to regulate its own secretion and provide evidence for a direct inhibitory effect of GH at the level of the bovine pituitary. | lld:pubmed |
| pubmed-article:1876236 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1876236 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1876236 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1876236 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1876236 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1876236 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1876236 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1876236 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1876236 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1876236 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:1876236 | pubmed:issn | 0028-3835 | lld:pubmed |
| pubmed-article:1876236 | pubmed:author | pubmed-author:WehrenbergW... | lld:pubmed |
| pubmed-article:1876236 | pubmed:author | pubmed-author:RosenthalS... | lld:pubmed |
| pubmed-article:1876236 | pubmed:author | pubmed-author:SilvermanB... | lld:pubmed |
| pubmed-article:1876236 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1876236 | pubmed:volume | 53 | lld:pubmed |
| pubmed-article:1876236 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1876236 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1876236 | pubmed:pagination | 597-600 | lld:pubmed |
| pubmed-article:1876236 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:1876236 | pubmed:meshHeading | pubmed-meshheading:1876236-... | lld:pubmed |
| pubmed-article:1876236 | pubmed:meshHeading | pubmed-meshheading:1876236-... | lld:pubmed |
| pubmed-article:1876236 | pubmed:meshHeading | pubmed-meshheading:1876236-... | lld:pubmed |
| pubmed-article:1876236 | pubmed:meshHeading | pubmed-meshheading:1876236-... | lld:pubmed |
| pubmed-article:1876236 | pubmed:meshHeading | pubmed-meshheading:1876236-... | lld:pubmed |
| pubmed-article:1876236 | pubmed:meshHeading | pubmed-meshheading:1876236-... | lld:pubmed |
| pubmed-article:1876236 | pubmed:meshHeading | pubmed-meshheading:1876236-... | lld:pubmed |
| pubmed-article:1876236 | pubmed:meshHeading | pubmed-meshheading:1876236-... | lld:pubmed |
| pubmed-article:1876236 | pubmed:meshHeading | pubmed-meshheading:1876236-... | lld:pubmed |
| pubmed-article:1876236 | pubmed:meshHeading | pubmed-meshheading:1876236-... | lld:pubmed |
| pubmed-article:1876236 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1876236 | pubmed:articleTitle | Exogenous growth hormone inhibits bovine but not murine pituitary growth hormone secretion in vitro: evidence for a direct feedback of growth hormone on the pituitary. | lld:pubmed |
| pubmed-article:1876236 | pubmed:affiliation | Department of Pediatrics, University of California, San Francisco. | lld:pubmed |
| pubmed-article:1876236 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1876236 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
