| pubmed-article:18759762 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18759762 | lifeskim:mentions | umls-concept:C0018957 | lld:lifeskim |
| pubmed-article:18759762 | lifeskim:mentions | umls-concept:C0855111 | lld:lifeskim |
| pubmed-article:18759762 | lifeskim:mentions | umls-concept:C0206153 | lld:lifeskim |
| pubmed-article:18759762 | lifeskim:mentions | umls-concept:C0596545 | lld:lifeskim |
| pubmed-article:18759762 | lifeskim:mentions | umls-concept:C1515895 | lld:lifeskim |
| pubmed-article:18759762 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:18759762 | pubmed:dateCreated | 2008-11-6 | lld:pubmed |
| pubmed-article:18759762 | pubmed:abstractText | Patients with relapsed diffuse large B-cell lymphoma (DLBCL) who have failed or are ineligible for autologous haematopoietic cell transplantation (HCT) have a poor prognosis. We examined the outcomes of non-myeloablative allogeneic HCT in this setting. Thirty-one patients with DLBCL and one patient with Burkitt lymphoma received allogeneic HCT following 2 Gy total body irradiation with or without fludarabine. Median age was 52 years. Twenty-four patients (75%) had undergone prior autologous HCT. Disease status at HCT was complete response (14/32, 44%), partial response (9/32, 28%), or refractory (9/32, 28%). Cumulative incidences of acute graft-versus-host disease (GVHD) grades II-IV, grades III-IV, and chronic GVHD were 53%, 19%, and 47% respectively. With a median follow-up of 45 months, 3-year estimated overall (OS) and progression-free survival (PFS) was 45% and 35% respectively. Three-year cumulative incidences of relapse and non-relapse mortality were 41% and 25% respectively. In multivariate models, chemosensitive disease and receipt of >or=4 lines of treatment before HCT were associated with better OS. Patients with chemosensitive disease had 3-year OS and PFS of 56% and 43% respectively. Non-myeloablative allogeneic HCT can produce long-term disease-free survival in patients with chemosensitive relapsed DLBCL who have failed or are ineligible for autologous HCT. | lld:pubmed |
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| pubmed-article:18759762 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18759762 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18759762 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:18759762 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18759762 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:18759762 | pubmed:issn | 1365-2141 | lld:pubmed |
| pubmed-article:18759762 | pubmed:author | pubmed-author:GooleyTedT | lld:pubmed |
| pubmed-article:18759762 | pubmed:author | pubmed-author:MaloneyDavid... | lld:pubmed |
| pubmed-article:18759762 | pubmed:author | pubmed-author:MarisMichaelM | lld:pubmed |
| pubmed-article:18759762 | pubmed:author | pubmed-author:SandmaierBren... | lld:pubmed |
| pubmed-article:18759762 | pubmed:author | pubmed-author:ChaunceyThoma... | lld:pubmed |
| pubmed-article:18759762 | pubmed:author | pubmed-author:BrunoBenedett... | lld:pubmed |
| pubmed-article:18759762 | pubmed:author | pubmed-author:BredesonChris... | lld:pubmed |
| pubmed-article:18759762 | pubmed:author | pubmed-author:StorbRainer... | lld:pubmed |
| pubmed-article:18759762 | pubmed:author | pubmed-author:LangeThoralfT | lld:pubmed |
| pubmed-article:18759762 | pubmed:author | pubmed-author:BouvierMichel... | lld:pubmed |
| pubmed-article:18759762 | pubmed:author | pubmed-author:ShizuruJudith... | lld:pubmed |
| pubmed-article:18759762 | pubmed:author | pubmed-author:AguraEdwardE | lld:pubmed |
| pubmed-article:18759762 | pubmed:author | pubmed-author:SahebiFirooze... | lld:pubmed |
| pubmed-article:18759762 | pubmed:author | pubmed-author:MaziarzRichar... | lld:pubmed |
| pubmed-article:18759762 | pubmed:author | pubmed-author:YeagerAndrewA | lld:pubmed |
| pubmed-article:18759762 | pubmed:author | pubmed-author:SorrorMohamed... | lld:pubmed |
| pubmed-article:18759762 | pubmed:author | pubmed-author:RezvaniAndrew... | lld:pubmed |
| pubmed-article:18759762 | pubmed:author | pubmed-author:NorasetthadaL... | lld:pubmed |
| pubmed-article:18759762 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18759762 | pubmed:volume | 143 | lld:pubmed |
| pubmed-article:18759762 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18759762 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18759762 | pubmed:pagination | 395-403 | lld:pubmed |
| pubmed-article:18759762 | pubmed:dateRevised | 2010-9-21 | lld:pubmed |
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