| pubmed-article:18758908 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18758908 | lifeskim:mentions | umls-concept:C0152035 | lld:lifeskim |
| pubmed-article:18758908 | lifeskim:mentions | umls-concept:C0001588 | lld:lifeskim |
| pubmed-article:18758908 | lifeskim:mentions | umls-concept:C0021760 | lld:lifeskim |
| pubmed-article:18758908 | lifeskim:mentions | umls-concept:C0034804 | lld:lifeskim |
| pubmed-article:18758908 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:18758908 | lifeskim:mentions | umls-concept:C0238806 | lld:lifeskim |
| pubmed-article:18758908 | lifeskim:mentions | umls-concept:C1335671 | lld:lifeskim |
| pubmed-article:18758908 | lifeskim:mentions | umls-concept:C0678951 | lld:lifeskim |
| pubmed-article:18758908 | lifeskim:mentions | umls-concept:C1510756 | lld:lifeskim |
| pubmed-article:18758908 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:18758908 | pubmed:dateCreated | 2008-9-1 | lld:pubmed |
| pubmed-article:18758908 | pubmed:abstractText | We assessed the main and interaction effects of interleukin-6 and estrogen receptor gene polymorphisms on bone mass accrual in Chinese adolescent girls. A total of 228 premenarche Chinese girls (9-11.5 years old) were recruited for a 2-year follow-up study. Bone mineral density (BMD) at the total body, lumbar spine (L1-L4), and total left hip were measured by dual-energy X-ray absorptiometry at baseline and follow-up. The -174G/C and -634C/G polymorphism of IL-6 gene, and PvuII and XbaI polymorphisms of the estrogen receptor (ER)-alpha gene, were determined. The -634C/G polymorphism of the IL-6 gene and PvuII polymorphism of ER-alpha gene were significantly associated with bone mass accrual after adjusting the potential confounding factors. Girls with pp genotype of ER-alpha gene had greater percentage accrual in BMD of total body (P = 0.010) and femoral intertrochanter (P = 0.038) than their PP and Pp counterparts. Girls with CC genotype of IL-6 -634G/C gene had higher percentage accrual in BMD of total body (P = 0.032) and femoral trochanter (P = 0.048) than their CG + GG counterparts. Significant interaction effects of IL-6 -634C/G polymorphism and ER-alpha PvuII polymorphism were observed on percentage change in BMD of total left hip (P = 0.009) and femoral intertrochanter (P = 0.007). The genotype CC (IL-6 -634C/G) x pp (ER-alpha PvuII) was associated with greater BMD accrual than other genotype combination in Chinese adolescent girls. We found that the IL-6 -634C/G and ER-alpha PvuII polymorphism were significantly associated with BMD accrual and that they have an interactional effect on BMD accrual in Chinese adolescent girls. | lld:pubmed |
| pubmed-article:18758908 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18758908 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18758908 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18758908 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18758908 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18758908 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18758908 | pubmed:issn | 0914-8779 | lld:pubmed |
| pubmed-article:18758908 | pubmed:author | pubmed-author:LiXingX | lld:pubmed |
| pubmed-article:18758908 | pubmed:author | pubmed-author:ChenYu-mingYM | lld:pubmed |
| pubmed-article:18758908 | pubmed:author | pubmed-author:SuYi-xiangYX | lld:pubmed |
| pubmed-article:18758908 | pubmed:author | pubmed-author:HeGuo-pengGP | lld:pubmed |
| pubmed-article:18758908 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18758908 | pubmed:volume | 26 | lld:pubmed |
| pubmed-article:18758908 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18758908 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18758908 | pubmed:pagination | 493-8 | lld:pubmed |
| pubmed-article:18758908 | pubmed:meshHeading | pubmed-meshheading:18758908... | lld:pubmed |
| pubmed-article:18758908 | pubmed:meshHeading | pubmed-meshheading:18758908... | lld:pubmed |
| pubmed-article:18758908 | pubmed:meshHeading | pubmed-meshheading:18758908... | lld:pubmed |
| pubmed-article:18758908 | pubmed:meshHeading | pubmed-meshheading:18758908... | lld:pubmed |
| pubmed-article:18758908 | pubmed:meshHeading | pubmed-meshheading:18758908... | lld:pubmed |
| pubmed-article:18758908 | pubmed:meshHeading | pubmed-meshheading:18758908... | lld:pubmed |
| pubmed-article:18758908 | pubmed:meshHeading | pubmed-meshheading:18758908... | lld:pubmed |
| pubmed-article:18758908 | pubmed:meshHeading | pubmed-meshheading:18758908... | lld:pubmed |
| pubmed-article:18758908 | pubmed:meshHeading | pubmed-meshheading:18758908... | lld:pubmed |
| pubmed-article:18758908 | pubmed:meshHeading | pubmed-meshheading:18758908... | lld:pubmed |
| pubmed-article:18758908 | pubmed:meshHeading | pubmed-meshheading:18758908... | lld:pubmed |
| pubmed-article:18758908 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18758908 | pubmed:articleTitle | Interaction of interleukin-6 and estrogen receptor gene polymorphisms on bone mass accrual in Chinese adolescent girls. | lld:pubmed |
| pubmed-article:18758908 | pubmed:affiliation | Department of Nutrition, School of Public Health, Sun Yat-sen University, 74 Zhongshan Rd 2, Guangzhou, China. | lld:pubmed |
| pubmed-article:18758908 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18758908 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:2099 | entrezgene:pubmed | pubmed-article:18758908 | lld:entrezgene |
| entrez-gene:3569 | entrezgene:pubmed | pubmed-article:18758908 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:18758908 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:18758908 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:18758908 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:18758908 | lld:entrezgene |
