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pubmed-article:18758174pubmed:abstractTextThe Mus musculus and Rattus norvegicus genomes have been extensively studied, yet despite the emergence of Peromyscus maniculatus as an NIH model for genome sequencing and biomedical research much remains unknown about the genome organization of Peromyscines. Contrary to their phylogenetic relationship, the genomes of Rattus and Peromyscus appear more similar at the gross karyotypic level than either does to Mus. We set out to define the chromosome homologies between Peromyscus, Mus and Rattus. Reciprocal cross-species chromosome painting and G-band homology assignments were used to delineate the conserved chromosome homology map between P. maniculatus and M. musculus. These data show that each species has undergone extensive chromosome rearrangements since they last shared a common ancestor 25 million years ago (mya). This analysis coupled with an inferred homology map with Rattus revealed a high level of chromosome conservation between Rattus and Peromyscus and indicated that the chromosomes of Mus are highly derived.lld:pubmed
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pubmed-article:18758174pubmed:statusMEDLINElld:pubmed
pubmed-article:18758174pubmed:issn1424-859Xlld:pubmed
pubmed-article:18758174pubmed:authorpubmed-author:O'NeillM JMJlld:pubmed
pubmed-article:18758174pubmed:authorpubmed-author:SwanW GWGlld:pubmed
pubmed-article:18758174pubmed:authorpubmed-author:DerroR ARAlld:pubmed
pubmed-article:18758174pubmed:authorpubmed-author:O'NeillR JRJlld:pubmed
pubmed-article:18758174pubmed:authorpubmed-author:RamsdellC MCMlld:pubmed
pubmed-article:18758174pubmed:authorpubmed-author:O'BrienP C...lld:pubmed
pubmed-article:18758174pubmed:authorpubmed-author:MlynarskiE...lld:pubmed
pubmed-article:18758174pubmed:authorpubmed-author:ObergfellC...lld:pubmed
pubmed-article:18758174pubmed:copyrightInfoCopyright 2008 S. Karger AG, Basel.lld:pubmed
pubmed-article:18758174pubmed:issnTypeElectroniclld:pubmed
pubmed-article:18758174pubmed:volume121lld:pubmed
pubmed-article:18758174pubmed:ownerNLMlld:pubmed
pubmed-article:18758174pubmed:authorsCompleteYlld:pubmed
pubmed-article:18758174pubmed:pagination288-92lld:pubmed
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pubmed-article:18758174pubmed:year2008lld:pubmed
pubmed-article:18758174pubmed:articleTitlePeromyscus maniculatus--Mus musculus chromosome homology map derived from reciprocal cross species chromosome painting.lld:pubmed
pubmed-article:18758174pubmed:affiliationDepartment of Molecular and Cell Biology, University of Connecticut, Storrs, CT 06269, USA.lld:pubmed
pubmed-article:18758174pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:18758174pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
pubmed-article:18758174pubmed:publicationTypeResearch Support, N.I.H., Extramurallld:pubmed