| pubmed-article:18758071 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18758071 | lifeskim:mentions | umls-concept:C0036572 | lld:lifeskim |
| pubmed-article:18758071 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:18758071 | lifeskim:mentions | umls-concept:C2002638 | lld:lifeskim |
| pubmed-article:18758071 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:18758071 | pubmed:dateCreated | 2008-9-1 | lld:pubmed |
| pubmed-article:18758071 | pubmed:abstractText | Sanjoinine A is a component of the alkaloid fraction of Zizyphi Spinosi Semen. This experiment was performed to investigate whether sanjoinine A acts as an anticonvulsive in the N-methyl-D-aspartate (NMDA)-induced experimental seizure model. We also examined whether it protects against seizure-form electroencephalogram (EEG) alterations induced by NMDA in vivo and/or cell killing due to NMDA in cultured cerebellar granule cells. Administration of sanjoinine A increased the survival rate and the latency of seizure onset, and decreased the seizure scores and the weight-loss induced by NMDA in mice, in a dose-dependent manner. In addition, sanjoinine A blocked seizure-form EEG alterations induced by NMDA and inhibited NMDA-induced cell killing in cultured rat cerebellar granule cells, measured by both the trypan blue exclusion test and the 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) assay. Moreover, sanjoinine A inhibited the elevation of intracellular calcium influx induced by NMDA, which was measured using a fluorescent dye, Furo 3-AM. It is suggested that sanjoinine A protects against NMDA-induced seizures by inhibiting intracellular calcium influx. | lld:pubmed |
| pubmed-article:18758071 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18758071 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18758071 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18758071 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18758071 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18758071 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18758071 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18758071 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18758071 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18758071 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18758071 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18758071 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18758071 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18758071 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:18758071 | pubmed:issn | 0918-6158 | lld:pubmed |
| pubmed-article:18758071 | pubmed:author | pubmed-author:HongJin-TaeJT | lld:pubmed |
| pubmed-article:18758071 | pubmed:author | pubmed-author:OhKi-WanKW | lld:pubmed |
| pubmed-article:18758071 | pubmed:author | pubmed-author:KimYun-BaeYB | lld:pubmed |
| pubmed-article:18758071 | pubmed:author | pubmed-author:MaYuanY | lld:pubmed |
| pubmed-article:18758071 | pubmed:author | pubmed-author:NamSang-YoonS... | lld:pubmed |
| pubmed-article:18758071 | pubmed:author | pubmed-author:KimYounghoonY | lld:pubmed |
| pubmed-article:18758071 | pubmed:author | pubmed-author:YunSung-RyulS... | lld:pubmed |
| pubmed-article:18758071 | pubmed:author | pubmed-author:ChoiHeesukH | lld:pubmed |
| pubmed-article:18758071 | pubmed:author | pubmed-author:LeeKinamK | lld:pubmed |
| pubmed-article:18758071 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18758071 | pubmed:volume | 31 | lld:pubmed |
| pubmed-article:18758071 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18758071 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18758071 | pubmed:pagination | 1749-54 | lld:pubmed |
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| pubmed-article:18758071 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18758071 | pubmed:articleTitle | Protective effects of sanjoinine A against N-methyl-D-aspartate-induced seizure. | lld:pubmed |
| pubmed-article:18758071 | pubmed:affiliation | Research Institute of Veterinary Medicine, Chungbuk National University, Cheongju, South Korea. | lld:pubmed |
| pubmed-article:18758071 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18758071 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
