| pubmed-article:18754742 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18754742 | lifeskim:mentions | umls-concept:C0074449 | lld:lifeskim |
| pubmed-article:18754742 | lifeskim:mentions | umls-concept:C0027882 | lld:lifeskim |
| pubmed-article:18754742 | lifeskim:mentions | umls-concept:C0927232 | lld:lifeskim |
| pubmed-article:18754742 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:18754742 | lifeskim:mentions | umls-concept:C0001721 | lld:lifeskim |
| pubmed-article:18754742 | lifeskim:mentions | umls-concept:C0061338 | lld:lifeskim |
| pubmed-article:18754742 | lifeskim:mentions | umls-concept:C0392752 | lld:lifeskim |
| pubmed-article:18754742 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:18754742 | pubmed:dateCreated | 2008-10-15 | lld:pubmed |
| pubmed-article:18754742 | pubmed:abstractText | Affinity-purified Shiga toxin (Stx) 2 given intraperitoneally to mice caused weight loss and hind-limb paralysis followed by death. Globotriaosylceramide (Gb(3)), the receptor for Stx2, was localized to neurons of the central nervous system (CNS) of normal mice. Gb3 was not found in astrocytes or endothelial cells of the CNS. In human cadaver CNS, we found Gb(3) in neurons and endothelial cells. Mouse Gb(3) localization was confirmed by immunoelectron microscopy. In Stx2-exposed mice, anti-Stx2-gold immunoreaction was positive in neurons. During paralysis, after Stx2 injection, multiple glial nuclei were observed surrounding motoneurons by electron microscopy. Also revealed was a lamellipodia-like process physically inhibiting the synaptic connection of motoneurons. Ca2+ imaging of cerebral astrocytic end-feet in Stx2-treated mouse brains suggested that the toxin increased neurotransmitter release from neurons. In this article, we propose that the neuron is a primary target of Stx2, affecting neuronal function and leading to paralysis. | lld:pubmed |
| pubmed-article:18754742 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18754742 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18754742 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18754742 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18754742 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18754742 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18754742 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18754742 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18754742 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18754742 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18754742 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18754742 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18754742 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18754742 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18754742 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18754742 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18754742 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18754742 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18754742 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18754742 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18754742 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18754742 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18754742 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18754742 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18754742 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18754742 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18754742 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18754742 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18754742 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18754742 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18754742 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18754742 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18754742 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18754742 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18754742 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18754742 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18754742 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18754742 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18754742 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18754742 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18754742 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18754742 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18754742 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18754742 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18754742 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18754742 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18754742 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18754742 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18754742 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18754742 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18754742 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18754742 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18754742 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18754742 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18754742 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:18754742 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18754742 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18754742 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18754742 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18754742 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18754742 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:18754742 | pubmed:issn | 0022-1899 | lld:pubmed |
| pubmed-article:18754742 | pubmed:author | pubmed-author:NelsonMark... | lld:pubmed |
| pubmed-article:18754742 | pubmed:author | pubmed-author:BonevAdrian... | lld:pubmed |
| pubmed-article:18754742 | pubmed:author | pubmed-author:ObrigTom GTG | lld:pubmed |
| pubmed-article:18754742 | pubmed:author | pubmed-author:KeepersTiffan... | lld:pubmed |
| pubmed-article:18754742 | pubmed:author | pubmed-author:TohyamaKoujir... | lld:pubmed |
| pubmed-article:18754742 | pubmed:author | pubmed-author:SatoShigehiro... | lld:pubmed |
| pubmed-article:18754742 | pubmed:author | pubmed-author:ObataFumikoF | lld:pubmed |
| pubmed-article:18754742 | pubmed:author | pubmed-author:GrossLisa KLK | lld:pubmed |
| pubmed-article:18754742 | pubmed:author | pubmed-author:KollingGlynis... | lld:pubmed |
| pubmed-article:18754742 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18754742 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:18754742 | pubmed:volume | 198 | lld:pubmed |
| pubmed-article:18754742 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18754742 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18754742 | pubmed:pagination | 1398-406 | lld:pubmed |
| pubmed-article:18754742 | pubmed:dateRevised | 2011-4-5 | lld:pubmed |
| pubmed-article:18754742 | pubmed:meshHeading | pubmed-meshheading:18754742... | lld:pubmed |
| pubmed-article:18754742 | pubmed:meshHeading | pubmed-meshheading:18754742... | lld:pubmed |
| pubmed-article:18754742 | pubmed:meshHeading | pubmed-meshheading:18754742... | lld:pubmed |
| pubmed-article:18754742 | pubmed:meshHeading | pubmed-meshheading:18754742... | lld:pubmed |
| pubmed-article:18754742 | pubmed:meshHeading | pubmed-meshheading:18754742... | lld:pubmed |
| pubmed-article:18754742 | pubmed:meshHeading | pubmed-meshheading:18754742... | lld:pubmed |
| pubmed-article:18754742 | pubmed:meshHeading | pubmed-meshheading:18754742... | lld:pubmed |
| pubmed-article:18754742 | pubmed:meshHeading | pubmed-meshheading:18754742... | lld:pubmed |
| pubmed-article:18754742 | pubmed:meshHeading | pubmed-meshheading:18754742... | lld:pubmed |
| pubmed-article:18754742 | pubmed:meshHeading | pubmed-meshheading:18754742... | lld:pubmed |
| pubmed-article:18754742 | pubmed:meshHeading | pubmed-meshheading:18754742... | lld:pubmed |
