| pubmed-article:18753356 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18753356 | lifeskim:mentions | umls-concept:C0026926 | lld:lifeskim |
| pubmed-article:18753356 | lifeskim:mentions | umls-concept:C1708726 | lld:lifeskim |
| pubmed-article:18753356 | lifeskim:mentions | umls-concept:C0017431 | lld:lifeskim |
| pubmed-article:18753356 | lifeskim:mentions | umls-concept:C0035970 | lld:lifeskim |
| pubmed-article:18753356 | lifeskim:mentions | umls-concept:C1552603 | lld:lifeskim |
| pubmed-article:18753356 | lifeskim:mentions | umls-concept:C1706202 | lld:lifeskim |
| pubmed-article:18753356 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:18753356 | pubmed:dateCreated | 2008-10-31 | lld:pubmed |
| pubmed-article:18753356 | pubmed:abstractText | The Beijing genotype is a globally spread lineage of Mycobacterium tuberculosis. In Russia, these strains constitute half of the local population of M. tuberculosis; they are associated with multidrug resistance and show increased transmissibility. Here, we analyzed traditional and new markers for the rapid and simple genotyping of the Beijing strains. A representative sample of 120 Beijing genotype strains was selected from a local IS6110-restriction fragment length (RFLP) database at the St. Petersburg Pasteur Institute. These strains were subjected to variable-number tandem-repeat (VNTR) typing using 24 loci of a newly proposed format and three hypervariable (HV) loci (QUB-3232, VNTR-3820, and VNTR-4120). Ten of the 27 VNTR loci were monomorphic, while five loci, MIRU26, QUB-26, QUB-3232, VNTR-3820, and VNTR-4120, were the most polymorphic (Hunter Gaston index, >0.5). VNTR typing allowed us to differentiate between two large IS6110-RFLP clusters known to be prevalent across the entire country (clusters B0/W148 and A0) and identified in 27 and 23% of strains, respectively, in the Beijing genotype database. The B0/W148 strains were grouped closely in the VNTR dendrogram and could be distinguished by a characteristic signature of the loci MIRU26 and QUB-26. Consequently, this clinically important IS6110-RFLP variant, B0/W148, likely presents a successful clonal group within the M. tuberculosis Beijing lineage that is widespread in Russia. To conclude, the IS6110-RFLP method and VNTR typing using a reduced set of the most polymorphic loci complement each other for the high-resolution epidemiological typing of the M. tuberculosis Beijing genotype strains circulating in or imported from Russia. | lld:pubmed |
| pubmed-article:18753356 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18753356 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18753356 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18753356 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18753356 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:18753356 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18753356 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:18753356 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:18753356 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18753356 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18753356 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18753356 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18753356 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18753356 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18753356 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18753356 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18753356 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18753356 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18753356 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18753356 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:18753356 | pubmed:issn | 1098-660X | lld:pubmed |
| pubmed-article:18753356 | pubmed:author | pubmed-author:RastogiNalinN | lld:pubmed |
| pubmed-article:18753356 | pubmed:author | pubmed-author:NarvskayaOlga... | lld:pubmed |
| pubmed-article:18753356 | pubmed:author | pubmed-author:MokrousovIgor... | lld:pubmed |
| pubmed-article:18753356 | pubmed:author | pubmed-author:OttenTatianaT | lld:pubmed |
| pubmed-article:18753356 | pubmed:author | pubmed-author:VyazovayaAnna... | lld:pubmed |
| pubmed-article:18753356 | pubmed:author | pubmed-author:MilletJulieJ | lld:pubmed |
| pubmed-article:18753356 | pubmed:author | pubmed-author:VishnevskyBor... | lld:pubmed |
| pubmed-article:18753356 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18753356 | pubmed:volume | 46 | lld:pubmed |
| pubmed-article:18753356 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18753356 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18753356 | pubmed:pagination | 3576-84 | lld:pubmed |
| pubmed-article:18753356 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:18753356 | pubmed:meshHeading | pubmed-meshheading:18753356... | lld:pubmed |
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| pubmed-article:18753356 | pubmed:meshHeading | pubmed-meshheading:18753356... | lld:pubmed |
| pubmed-article:18753356 | pubmed:meshHeading | pubmed-meshheading:18753356... | lld:pubmed |
| pubmed-article:18753356 | pubmed:meshHeading | pubmed-meshheading:18753356... | lld:pubmed |
| pubmed-article:18753356 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18753356 | pubmed:articleTitle | Mycobacterium tuberculosis Beijing genotype in Russia: in search of informative variable-number tandem-repeat loci. | lld:pubmed |
| pubmed-article:18753356 | pubmed:affiliation | Laboratory of Molecular Microbiology, St. Petersburg Pasteur Institute, St. Petersburg 197101, Russia. igormokrousov@yahoo.com | lld:pubmed |
| pubmed-article:18753356 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18753356 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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