| pubmed-article:18752546 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18752546 | lifeskim:mentions | umls-concept:C0205943 | lld:lifeskim |
| pubmed-article:18752546 | lifeskim:mentions | umls-concept:C0744421 | lld:lifeskim |
| pubmed-article:18752546 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:18752546 | pubmed:dateCreated | 2008-11-28 | lld:pubmed |
| pubmed-article:18752546 | pubmed:abstractText | Chinook salmon from New Zealand were shown to have a generalized membranous glomerulonephritis that was most severe in large fish. Marked thickening of the glomerular basement membrane was the most consistent lesion, with the presence of an electron-dense deposit beneath the capillary endothelium.Severely affected glomeruli also had expansion of the mesangium and loss of capillaries,synechiae of the visceral and parietal epithelium and mild fibrosis of Bowmans capsule. Chinook salmon from British Columbia, Canada with bacterial kidney disease caused by Renibacterium salmoninarum had similar histological lesions. They also had thickened glomerular basement membranes that were recognized by rabbit antiserum to rainbow trout immunoglobulin. This was true only when frozen sections of kidney were used and not formalin-fixed tissue. An attempt to experimentally produce a glomerulopathy in rainbow trout by repeated immunization with killed R. salmoninarum was not successful. Case records from the Fish Pathology Laboratory at the University of Guelph over a 10-year period revealed that a range of species were diagnosed with glomerulopathies similar to those seen in Chinook salmon. The majority of these cases were determined to have chronic inflammatory disease. This report has identified the presence of immunoglobulin within thickened basement membranes of Chinook salmon with glomerulonephritis and supports the existence of type III hypersensitivity in fish. | lld:pubmed |
| pubmed-article:18752546 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18752546 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18752546 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18752546 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18752546 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18752546 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:18752546 | pubmed:issn | 1365-2761 | lld:pubmed |
| pubmed-article:18752546 | pubmed:author | pubmed-author:HuberPP | lld:pubmed |
| pubmed-article:18752546 | pubmed:author | pubmed-author:FergusonH WHW | lld:pubmed |
| pubmed-article:18752546 | pubmed:author | pubmed-author:RussellSS | lld:pubmed |
| pubmed-article:18752546 | pubmed:author | pubmed-author:LumsdenJ SJS | lld:pubmed |
| pubmed-article:18752546 | pubmed:author | pubmed-author:OstlandV EVE | lld:pubmed |
| pubmed-article:18752546 | pubmed:author | pubmed-author:MinamikawaMM | lld:pubmed |
| pubmed-article:18752546 | pubmed:author | pubmed-author:WybourneB ABA | lld:pubmed |
| pubmed-article:18752546 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18752546 | pubmed:volume | 31 | lld:pubmed |
| pubmed-article:18752546 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18752546 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18752546 | pubmed:pagination | 889-98 | lld:pubmed |
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| pubmed-article:18752546 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18752546 | pubmed:articleTitle | An immune-complex glomerulonephritis of Chinook salmon, Oncorhynchus tshawytscha (Walbaum). | lld:pubmed |
| pubmed-article:18752546 | pubmed:affiliation | Institute of Animal, Veterinary, and Biomedical Sciences, Massey University, Palmerston North, New Zealand. jsl@uoguelph.ca | lld:pubmed |
| pubmed-article:18752546 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18752546 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
