| pubmed-article:1873206 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1873206 | lifeskim:mentions | umls-concept:C0221920 | lld:lifeskim |
| pubmed-article:1873206 | lifeskim:mentions | umls-concept:C0029282 | lld:lifeskim |
| pubmed-article:1873206 | lifeskim:mentions | umls-concept:C0332237 | lld:lifeskim |
| pubmed-article:1873206 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:1873206 | lifeskim:mentions | umls-concept:C1522168 | lld:lifeskim |
| pubmed-article:1873206 | lifeskim:mentions | umls-concept:C1704747 | lld:lifeskim |
| pubmed-article:1873206 | lifeskim:mentions | umls-concept:C2917448 | lld:lifeskim |
| pubmed-article:1873206 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:1873206 | pubmed:dateCreated | 1991-9-23 | lld:pubmed |
| pubmed-article:1873206 | pubmed:abstractText | The efficacy of MC903, a vitamin D3 analogue, in reducing hyperproliferation as determined by levels of ornithine decarboxylase (ODC) was investigated in a double-blind study of 15 patients with chronic plaque psoriasis. The lesions of psoriasis were treated for 8 weeks with MC903 in one of two different cream bases or with a placebo cream. Biopsies were taken before and after treatment. In addition an uninvolved area of skin was treated during the last 3 weeks and this as well as control areas were then sellotape stripped and biopsied after 8 h. Clinical improvement was seen in eight out of 11 patients treated with MC903 but there was no reduction in the level of ODC in psoriatic lesions after 8 weeks of treatment. The levels of ODC in the tape-stripped uninvolved skin after 3 weeks of treatment with MC903 averaged 22.5 +/- 4.2 pmol/min/mg protein as compared to 58.6 +/- 12.6 pmol/min/mg protein (P = 0.004). The trauma-induced induction of ODC activity was markedly inhibited by the application of MC903. | lld:pubmed |
| pubmed-article:1873206 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1873206 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1873206 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1873206 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1873206 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1873206 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1873206 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1873206 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:1873206 | pubmed:issn | 0007-0963 | lld:pubmed |
| pubmed-article:1873206 | pubmed:author | pubmed-author:ArnoldW PWP | lld:pubmed |
| pubmed-article:1873206 | pubmed:author | pubmed-author:van de... | lld:pubmed |
| pubmed-article:1873206 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1873206 | pubmed:volume | 125 | lld:pubmed |
| pubmed-article:1873206 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1873206 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1873206 | pubmed:pagination | 6-8 | lld:pubmed |
| pubmed-article:1873206 | pubmed:dateRevised | 2004-11-17 | lld:pubmed |
| pubmed-article:1873206 | pubmed:meshHeading | pubmed-meshheading:1873206-... | lld:pubmed |
| pubmed-article:1873206 | pubmed:meshHeading | pubmed-meshheading:1873206-... | lld:pubmed |
| pubmed-article:1873206 | pubmed:meshHeading | pubmed-meshheading:1873206-... | lld:pubmed |
| pubmed-article:1873206 | pubmed:meshHeading | pubmed-meshheading:1873206-... | lld:pubmed |
| pubmed-article:1873206 | pubmed:meshHeading | pubmed-meshheading:1873206-... | lld:pubmed |
| pubmed-article:1873206 | pubmed:meshHeading | pubmed-meshheading:1873206-... | lld:pubmed |
| pubmed-article:1873206 | pubmed:meshHeading | pubmed-meshheading:1873206-... | lld:pubmed |
| pubmed-article:1873206 | pubmed:meshHeading | pubmed-meshheading:1873206-... | lld:pubmed |
| pubmed-article:1873206 | pubmed:meshHeading | pubmed-meshheading:1873206-... | lld:pubmed |
| pubmed-article:1873206 | pubmed:meshHeading | pubmed-meshheading:1873206-... | lld:pubmed |
| pubmed-article:1873206 | pubmed:meshHeading | pubmed-meshheading:1873206-... | lld:pubmed |
| pubmed-article:1873206 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1873206 | pubmed:articleTitle | The induction of epidermal ornithine decarboxylase following tape stripping is inhibited by a topical vitamin D3 analogue (MC903). | lld:pubmed |
| pubmed-article:1873206 | pubmed:affiliation | Department of Dermatology, University Hospital Nijmegen, The Netherlands. | lld:pubmed |
| pubmed-article:1873206 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1873206 | pubmed:publicationType | Clinical Trial | lld:pubmed |
| pubmed-article:1873206 | pubmed:publicationType | Randomized Controlled Trial | lld:pubmed |
