Linked Life Data

18728182

Source:http://linkedlifedata.com/resource/pubmed/id/18728182

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:18728182rdf:typepubmed:Citationlld:pubmed
pubmed-article:18728182lifeskim:mentionsumls-concept:C0026764lld:lifeskim
pubmed-article:18728182lifeskim:mentionsumls-concept:C0017337lld:lifeskim
pubmed-article:18728182lifeskim:mentionsumls-concept:C1101610lld:lifeskim
pubmed-article:18728182lifeskim:mentionsumls-concept:C0699748lld:lifeskim
pubmed-article:18728182lifeskim:mentionsumls-concept:C0332281lld:lifeskim
pubmed-article:18728182lifeskim:mentionsumls-concept:C0851285lld:lifeskim
pubmed-article:18728182lifeskim:mentionsumls-concept:C1511545lld:lifeskim
pubmed-article:18728182pubmed:issue35lld:pubmed
pubmed-article:18728182pubmed:dateCreated2008-9-3lld:pubmed
pubmed-article:18728182pubmed:abstractTextProgress in understanding the biology of multiple myeloma (MM), a plasma cell malignancy, has been slow. The discovery of microRNAs (miRNAs), a class of small noncoding RNAs targeting multiple mRNAs, has revealed a new level of gene expression regulation. To determine whether miRNAs play a role in the malignant transformation of plasma cells (PCs), we have used both miRNA microarrays and quantitative real time PCR to profile miRNA expression in MM-derived cell lines (n = 49) and CD138+ bone marrow PCs from subjects with MM (n = 16), monoclonal gammopathy of undetermined significance (MGUS) (n = 6), and normal donors (n = 6). We identified overexpression of miR-21, miR-106b approximately 25 cluster, miR-181a and b in MM and MGUS samples with respect to healthy PCs. Selective up-regulation of miR-32 and miR-17 approximately 92 cluster was identified in MM subjects and cell lines but not in MGUS subjects or healthy PCs. Furthermore, two miRNAs, miR-19a and 19b, that are part of the miR-17 approximately 92 cluster, were shown to down regulate expression of SOCS-1, a gene frequently silenced in MM that plays a critical role as inhibitor of IL-6 growth signaling. We also identified p300-CBP-associated factor, a gene involved in p53 regulation, as a bona fide target of the miR106b approximately 25 cluster, miR-181a and b, and miR-32. Xenograft studies using human MM cell lines treated with miR-19a and b, and miR-181a and b antagonists resulted in significant suppression of tumor growth in nude mice. In summary, we have described a MM miRNA signature, which includes miRNAs that modulate the expression of proteins critical to myeloma pathogenesis.lld:pubmed
pubmed-article:18728182pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18728182pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18728182pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18728182pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18728182pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18728182pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18728182pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18728182pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18728182pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18728182pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18728182pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18728182pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18728182pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18728182pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18728182pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18728182pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18728182pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18728182pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18728182pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18728182pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18728182pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18728182pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18728182pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18728182pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18728182pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18728182pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18728182pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18728182pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18728182pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18728182pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18728182pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18728182pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18728182pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18728182pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18728182pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18728182pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18728182pubmed:languageenglld:pubmed
pubmed-article:18728182pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18728182pubmed:citationSubsetIMlld:pubmed
pubmed-article:18728182pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18728182pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18728182pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18728182pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18728182pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18728182pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18728182pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18728182pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18728182pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18728182pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18728182pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18728182pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18728182pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18728182pubmed:statusMEDLINElld:pubmed
pubmed-article:18728182pubmed:monthSeplld:pubmed
pubmed-article:18728182pubmed:issn1091-6490lld:pubmed
pubmed-article:18728182pubmed:authorpubmed-author:LadettoMarcoMlld:pubmed
pubmed-article:18728182pubmed:authorpubmed-author:MunkerReinhol...lld:pubmed
pubmed-article:18728182pubmed:authorpubmed-author:ZanesiNicolaNlld:pubmed
pubmed-article:18728182pubmed:authorpubmed-author:GarzonRamiroRlld:pubmed
pubmed-article:18728182pubmed:authorpubmed-author:CroceCarlo...lld:pubmed
pubmed-article:18728182pubmed:authorpubmed-author:VoliniaStefan...lld:pubmed
pubmed-article:18728182pubmed:authorpubmed-author:AlderHansjuer...lld:pubmed
pubmed-article:18728182pubmed:authorpubmed-author:BoccadoroMari...lld:pubmed
pubmed-article:18728182pubmed:authorpubmed-author:DrandiDaniela...lld:pubmed
pubmed-article:18728182pubmed:authorpubmed-author:PalumboAntoni...lld:pubmed
pubmed-article:18728182pubmed:authorpubmed-author:SuhSung-SukSSlld:pubmed
pubmed-article:18728182pubmed:authorpubmed-author:PichiorriFlav...lld:pubmed
pubmed-article:18728182pubmed:authorpubmed-author:AqeilanRami...lld:pubmed
pubmed-article:18728182pubmed:authorpubmed-author:KuehlMichaelMlld:pubmed
pubmed-article:18728182pubmed:authorpubmed-author:HaganJohn PJPlld:pubmed
pubmed-article:18728182pubmed:authorpubmed-author:PalumboTizian...lld:pubmed
pubmed-article:18728182pubmed:authorpubmed-author:TaccioliCrist...lld:pubmed
pubmed-article:18728182pubmed:issnTypeElectroniclld:pubmed
pubmed-article:18728182pubmed:day2lld:pubmed
pubmed-article:18728182pubmed:volume105lld:pubmed
pubmed-article:18728182pubmed:ownerNLMlld:pubmed
pubmed-article:18728182pubmed:authorsCompleteYlld:pubmed
pubmed-article:18728182pubmed:pagination12885-90lld:pubmed
pubmed-article:18728182pubmed:dateRevised2009-11-19lld:pubmed
pubmed-article:18728182pubmed:meshHeadingpubmed-meshheading:18728182...lld:pubmed
pubmed-article:18728182pubmed:meshHeadingpubmed-meshheading:18728182...lld:pubmed
pubmed-article:18728182pubmed:meshHeadingpubmed-meshheading:18728182...lld:pubmed
pubmed-article:18728182pubmed:meshHeadingpubmed-meshheading:18728182...lld:pubmed
pubmed-article:18728182pubmed:meshHeadingpubmed-meshheading:18728182...lld:pubmed
pubmed-article:18728182pubmed:meshHeadingpubmed-meshheading:18728182...lld:pubmed
pubmed-article:18728182pubmed:meshHeadingpubmed-meshheading:18728182...lld:pubmed
pubmed-article:18728182pubmed:meshHeadingpubmed-meshheading:18728182...lld:pubmed
pubmed-article:18728182pubmed:meshHeadingpubmed-meshheading:18728182...lld:pubmed
pubmed-article:18728182pubmed:meshHeadingpubmed-meshheading:18728182...lld:pubmed
More...