| pubmed-article:18719121 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18719121 | lifeskim:mentions | umls-concept:C0077503 | lld:lifeskim |
| pubmed-article:18719121 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:18719121 | lifeskim:mentions | umls-concept:C0670896 | lld:lifeskim |
| pubmed-article:18719121 | lifeskim:mentions | umls-concept:C1336664 | lld:lifeskim |
| pubmed-article:18719121 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:18719121 | pubmed:issue | 34 | lld:pubmed |
| pubmed-article:18719121 | pubmed:dateCreated | 2008-8-27 | lld:pubmed |
| pubmed-article:18719121 | pubmed:abstractText | Tumor necrosis factor receptor 1-associated death domain protein (TRADD) is the core adaptor recruited to TNF receptor 1 (TNFR1) upon TNFalpha stimulation. In cells from TRADD-deficient mice, TNFalpha-mediated apoptosis and TNFalpha-stimulated NF-kappaB, JNK, and ERK activation are defective. TRADD is also important for germinal center formation, DR3-mediated costimulation of T cells, and TNFalpha-mediated inflammatory responses in vivo. TRADD deficiency does not enhance IFNgamma-induced signaling. Importantly, TRADD has a novel role in TLR3 and TLR4 signaling. TRADD participates in the TLR4 complex formed upon LPS stimulation, and TRADD-deficient macrophages show impaired cytokine production in response to TLR ligands in vitro. Thus, TRADD is a multifunctional protein crucial both for TNFR1 signaling and other signaling pathways relevant to immune responses. | lld:pubmed |
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| pubmed-article:18719121 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:18719121 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18719121 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:18719121 | pubmed:issn | 1091-6490 | lld:pubmed |
| pubmed-article:18719121 | pubmed:author | pubmed-author:YamamotoKazuo... | lld:pubmed |
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| pubmed-article:18719121 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18719121 | pubmed:day | 26 | lld:pubmed |
| pubmed-article:18719121 | pubmed:volume | 105 | lld:pubmed |
| pubmed-article:18719121 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18719121 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18719121 | pubmed:pagination | 12429-34 | lld:pubmed |
| pubmed-article:18719121 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:18719121 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18719121 | pubmed:articleTitle | Beyond tumor necrosis factor receptor: TRADD signaling in toll-like receptors. | lld:pubmed |
| pubmed-article:18719121 | pubmed:affiliation | The Campbell Family Institute for Breast Cancer Research, University Health Network and Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada M5G 2C1. | lld:pubmed |
| pubmed-article:18719121 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18719121 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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