Linked Life Data

18718072

Source:http://linkedlifedata.com/resource/pubmed/id/18718072

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pubmed-article:18718072pubmed:abstractTextThe aim of this study was to investigate the relationship between the plasma levels of chemokine CCL-2/MCP-1 and acute graft-versus-host disease (aGVHD) and/or idiopathic pneumonia syndrome (IPS) after allogeneic hematopoietic stem cell transplantation (allo-HSCT). ELISA assays were used to detect the plasma level of CCL-2/MCP-1 of 22 patients who received allo-HSCT, including 14 patients without or with grade I, 8 patients with grade II - IV aGVHD, respectively. 8 out of 22 patients were also diagnosed with IPS clinically. The dynamic changes of the plasma levels of CCL-2/MCP-1 chemokine and its correlation with aGVHD and/or IPS were analysized retrospectively. The results showed that the plasma levels of CCL-2/MCP-1 in the patients with moderate and serious aGVHD (grade II - IV) significantly increased, as compared with that prior to allo-HSCT (p < 0.05). The plasma levels of CCL-2/MCP-1 in the patients with aGVHD and/or IPS were higher significantly than those without any of these complications (p = 0.001). The retrospective analysis indicated that the plasma levels of CCL-2/MCP-1 in the patients with IPS significantly increased (p = 0.006). It is concluded that plasma level of CCL-2/MCP-1 correlates with aGVHD and/or IPS, and plays a role in the pathogenesis of these complications.lld:pubmed
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pubmed-article:18718072pubmed:authorpubmed-author:LiYuanYlld:pubmed
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pubmed-article:18718072pubmed:articleTitle[Correlation of chemokine CCL-2/MCP-1 level in the plasma with aGVHD and idiophathic pneumonia syndrome after allogeneic hematopoietic stem cell transplantation].lld:pubmed
pubmed-article:18718072pubmed:affiliationDepartment of Hematology, Peking University First Hospital, Beijing 100034, China.lld:pubmed
pubmed-article:18718072pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:18718072pubmed:publicationTypeEnglish Abstractlld:pubmed
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