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18706523

Source:http://linkedlifedata.com/resource/pubmed/id/18706523

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pubmed-article:18706523pubmed:abstractTextWe studied the effect an inhibitor of Ras-GTPase (FPTIII, 1.5 mg/kg alt diem for 4 weeks) on mean arterial pressure (MAP), urine protein, vascular reactivity and cardiac function in streptozotocin (STZ)-induced diabetes in control normotensive (WKY) and spontaneously hypertensive rats (SHR). The increased urinary protein in STZ-treated WKY (D-WKY) and STZ-treated SHR (D-SHR) were significantly lower in FPTIII treated D-WKY and D-SHR. The abnormal vascular responsiveness to endothelin-1, angiotensin II, carbachol or histamine in isolated carotid artery from D-WKY and D-SHR was improved by chronic treatment with FPTIII. In isolated perfused hearts, recovery of left ventricular function from 40 min of global ischemia was significantly improved in FPTIII treated D-WKY and D-SHR. These results show that treatment with FPTIII can attenuate development of abnormal vascular reactivity and renal/cardiac dysfunction during simultaneous occurrence of hypertension and diabetes.lld:pubmed
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pubmed-article:18706523pubmed:authorpubmed-author:YousifMariam...lld:pubmed
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pubmed-article:18706523pubmed:articleTitleInhibition of Ras-GTPase signaling by FPTIII ameliorates development of cardiovascular dysfunction in diabetic-hypertensive rats.lld:pubmed
pubmed-article:18706523pubmed:affiliationDepartment of Pharmacology & Toxicology, Faculty of Medicine, Kuwait University, Kuwait. mariam@hsc.edu.kwlld:pubmed
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