| pubmed-article:18701545 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18701545 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:18701545 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:18701545 | lifeskim:mentions | umls-concept:C0013935 | lld:lifeskim |
| pubmed-article:18701545 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:18701545 | lifeskim:mentions | umls-concept:C1817161 | lld:lifeskim |
| pubmed-article:18701545 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:18701545 | pubmed:issue | 18 | lld:pubmed |
| pubmed-article:18701545 | pubmed:dateCreated | 2008-8-26 | lld:pubmed |
| pubmed-article:18701545 | pubmed:abstractText | In Xenopus and zebrafish embryos, elongation of the anterior-posterior body axis depends on convergent extension, a process that involves polarized cell movements and is regulated by non-canonical Wnt signaling. The mechanisms that control axis elongation of the mouse embryo are much less well understood. Here, we characterize the ENU-induced mouse mutation chato, which causes arrest at midgestation and defects characteristic of convergent extension mutants, including a shortened body axis, mediolaterally extended somites and an open neural tube. The chato mutation disrupts Zfp568, a Krüppel-associated box (KRAB) domain zinc-finger protein. Morphometric analysis revealed that the definitive endoderm of mouse wild-type embryos undergoes cell rearrangements that lead to convergent extension during early somite stages, and that these cell rearrangements fail in chato embryos. Although non-canonical Wnt signaling is important for convergent extension in the mouse notochord and neural plate, the results indicate that chato regulates body axis elongation in all embryonic tissues through a process independent of non-canonical Wnt signaling. | lld:pubmed |
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| pubmed-article:18701545 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18701545 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18701545 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18701545 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18701545 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18701545 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18701545 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:18701545 | pubmed:issn | 0950-1991 | lld:pubmed |
| pubmed-article:18701545 | pubmed:author | pubmed-author:AndersonKathr... | lld:pubmed |
| pubmed-article:18701545 | pubmed:author | pubmed-author:García-García... | lld:pubmed |
| pubmed-article:18701545 | pubmed:author | pubmed-author:ShibataMahoM | lld:pubmed |
| pubmed-article:18701545 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18701545 | pubmed:volume | 135 | lld:pubmed |
| pubmed-article:18701545 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18701545 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18701545 | pubmed:pagination | 3053-62 | lld:pubmed |
| pubmed-article:18701545 | pubmed:dateRevised | 2011-4-21 | lld:pubmed |
| pubmed-article:18701545 | pubmed:meshHeading | pubmed-meshheading:18701545... | lld:pubmed |
| pubmed-article:18701545 | pubmed:meshHeading | pubmed-meshheading:18701545... | lld:pubmed |
| pubmed-article:18701545 | pubmed:meshHeading | pubmed-meshheading:18701545... | lld:pubmed |
