| pubmed-article:18701271 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18701271 | lifeskim:mentions | umls-concept:C0055856 | lld:lifeskim |
| pubmed-article:18701271 | lifeskim:mentions | umls-concept:C2612061 | lld:lifeskim |
| pubmed-article:18701271 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:18701271 | pubmed:dateCreated | 2008-11-17 | lld:pubmed |
| pubmed-article:18701271 | pubmed:abstractText | The aim of the current study was to investigate the effect of 14-membered ring macrolide clarithromycin (CAM) on migration induced by human plasma fibronectin (HFn) or on contraction of human fetal lung fibroblasts (HFL-1). METHODS AND RESULTS: Using the blindwell chamber technique, CAM (10(-5) M) inhibited the migration of HFL-1 60.2+/-4.0% (p<0.05). Other antibiotics, such as ampicillin, minocycline or azithromycin had no effects on HFL-1 migration. The effect of CAM was concentration dependent. HFL-1 migration, stimulated by TXA(2) analog was also inhibited by CAM. Clarithromycin had no effect on HFL-1 mediated gel contraction that was another function of fibroblast at the wound area. CONCLUSIONS: Clarithromycin may contribute to the regulation of the wound healing response following injury by inhibiting fibroblast migration. These results could represent the therapeutic benefits of CAM. | lld:pubmed |
| pubmed-article:18701271 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18701271 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18701271 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18701271 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18701271 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18701271 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18701271 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18701271 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18701271 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18701271 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:18701271 | pubmed:issn | 1532-3064 | lld:pubmed |
| pubmed-article:18701271 | pubmed:author | pubmed-author:KippJ BJB | lld:pubmed |
| pubmed-article:18701271 | pubmed:author | pubmed-author:NagaseTakahid... | lld:pubmed |
| pubmed-article:18701271 | pubmed:author | pubmed-author:TakizawaHajim... | lld:pubmed |
| pubmed-article:18701271 | pubmed:author | pubmed-author:KohyamaTadash... | lld:pubmed |
| pubmed-article:18701271 | pubmed:author | pubmed-author:YamauchiYasuh... | lld:pubmed |
| pubmed-article:18701271 | pubmed:author | pubmed-author:ItakuraSusumu... | lld:pubmed |
| pubmed-article:18701271 | pubmed:author | pubmed-author:KamitaniSumik... | lld:pubmed |
| pubmed-article:18701271 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18701271 | pubmed:volume | 102 | lld:pubmed |
| pubmed-article:18701271 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18701271 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18701271 | pubmed:pagination | 1769-76 | lld:pubmed |
| pubmed-article:18701271 | pubmed:meshHeading | pubmed-meshheading:18701271... | lld:pubmed |
| pubmed-article:18701271 | pubmed:meshHeading | pubmed-meshheading:18701271... | lld:pubmed |
| pubmed-article:18701271 | pubmed:meshHeading | pubmed-meshheading:18701271... | lld:pubmed |
| pubmed-article:18701271 | pubmed:meshHeading | pubmed-meshheading:18701271... | lld:pubmed |
| pubmed-article:18701271 | pubmed:meshHeading | pubmed-meshheading:18701271... | lld:pubmed |
| pubmed-article:18701271 | pubmed:meshHeading | pubmed-meshheading:18701271... | lld:pubmed |
| pubmed-article:18701271 | pubmed:meshHeading | pubmed-meshheading:18701271... | lld:pubmed |
| pubmed-article:18701271 | pubmed:meshHeading | pubmed-meshheading:18701271... | lld:pubmed |
| pubmed-article:18701271 | pubmed:meshHeading | pubmed-meshheading:18701271... | lld:pubmed |
| pubmed-article:18701271 | pubmed:meshHeading | pubmed-meshheading:18701271... | lld:pubmed |
| pubmed-article:18701271 | pubmed:meshHeading | pubmed-meshheading:18701271... | lld:pubmed |
| pubmed-article:18701271 | pubmed:meshHeading | pubmed-meshheading:18701271... | lld:pubmed |
| pubmed-article:18701271 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18701271 | pubmed:articleTitle | Clarithromycin inhibits fibroblast migration. | lld:pubmed |
| pubmed-article:18701271 | pubmed:affiliation | Department of Respiratory Medicine, The University of Tokyo, Graduate School of Medicine, 7-3-1 Hongo Bunkyo-ku, Tokyo 113-8655, Japan. koyama-tky@umin.ac.jp | lld:pubmed |
| pubmed-article:18701271 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:18701271 | lld:pubmed |
