| pubmed-article:18701096 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18701096 | lifeskim:mentions | umls-concept:C0079427 | lld:lifeskim |
| pubmed-article:18701096 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:18701096 | lifeskim:mentions | umls-concept:C0334227 | lld:lifeskim |
| pubmed-article:18701096 | lifeskim:mentions | umls-concept:C0018270 | lld:lifeskim |
| pubmed-article:18701096 | lifeskim:mentions | umls-concept:C1527249 | lld:lifeskim |
| pubmed-article:18701096 | lifeskim:mentions | umls-concept:C0532025 | lld:lifeskim |
| pubmed-article:18701096 | lifeskim:mentions | umls-concept:C1149301 | lld:lifeskim |
| pubmed-article:18701096 | lifeskim:mentions | umls-concept:C0237477 | lld:lifeskim |
| pubmed-article:18701096 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:18701096 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:18701096 | pubmed:dateCreated | 2008-10-17 | lld:pubmed |
| pubmed-article:18701096 | pubmed:abstractText | Insulin-like growth factor binding protein-related protein 1 (IGFBP-rP1) is a potential tumor suppressor gene. This study attempted to explore a potential senescence-like role for IGFBP-rP1 in suppressing human colorectal cancer. Recombinant IGFBP-rP1 inhibited cell proliferation and induced G1 cell cycle arrest in RKO and CW2 cells. It induced a senescence-like phenotype by showing 2-fold higher beta-galactosidase activity in IGFBP-rP1-transfectants over that in control cells. Western blot confirmed down-regulation of phosphorylated retinoblastoma protein (pRB) and up-regulation of p53 in IGFBP-rP1-transfectants as compared with control cells. Thus, IGFBP-rP1 might be a key molecule in the cellular senescence pathway. Our results uncovered a novel molecular mechanism involving the altered expression of pRB and p53 for tumor suppressor gene IGFBP-rP1 in colorectal cancer. Restoration of IGFBP-rP1 function might have potential therapeutic significance in colorectal cancer. | lld:pubmed |
| pubmed-article:18701096 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18701096 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18701096 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18701096 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18701096 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18701096 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18701096 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18701096 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18701096 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:18701096 | pubmed:issn | 1096-0945 | lld:pubmed |
| pubmed-article:18701096 | pubmed:author | pubmed-author:DeyD KDK | lld:pubmed |
| pubmed-article:18701096 | pubmed:author | pubmed-author:LiuN BNB | lld:pubmed |
| pubmed-article:18701096 | pubmed:author | pubmed-author:XXX | lld:pubmed |
| pubmed-article:18701096 | pubmed:author | pubmed-author:DengHongH | lld:pubmed |
| pubmed-article:18701096 | pubmed:author | pubmed-author:HuangQiongQ | lld:pubmed |
| pubmed-article:18701096 | pubmed:author | pubmed-author:RuanWenjingW | lld:pubmed |
| pubmed-article:18701096 | pubmed:author | pubmed-author:LaiMaodeM | lld:pubmed |
| pubmed-article:18701096 | pubmed:author | pubmed-author:WangHongqiang... | lld:pubmed |
| pubmed-article:18701096 | pubmed:author | pubmed-author:LuBingjianB | lld:pubmed |
| pubmed-article:18701096 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18701096 | pubmed:volume | 85 | lld:pubmed |
| pubmed-article:18701096 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18701096 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18701096 | pubmed:pagination | 141-5 | lld:pubmed |
| pubmed-article:18701096 | pubmed:meshHeading | pubmed-meshheading:18701096... | lld:pubmed |
| pubmed-article:18701096 | pubmed:meshHeading | pubmed-meshheading:18701096... | lld:pubmed |
| pubmed-article:18701096 | pubmed:meshHeading | pubmed-meshheading:18701096... | lld:pubmed |
| pubmed-article:18701096 | pubmed:meshHeading | pubmed-meshheading:18701096... | lld:pubmed |
| pubmed-article:18701096 | pubmed:meshHeading | pubmed-meshheading:18701096... | lld:pubmed |
| pubmed-article:18701096 | pubmed:meshHeading | pubmed-meshheading:18701096... | lld:pubmed |
| pubmed-article:18701096 | pubmed:meshHeading | pubmed-meshheading:18701096... | lld:pubmed |
| pubmed-article:18701096 | pubmed:meshHeading | pubmed-meshheading:18701096... | lld:pubmed |
| pubmed-article:18701096 | pubmed:meshHeading | pubmed-meshheading:18701096... | lld:pubmed |
| pubmed-article:18701096 | pubmed:meshHeading | pubmed-meshheading:18701096... | lld:pubmed |
| pubmed-article:18701096 | pubmed:meshHeading | pubmed-meshheading:18701096... | lld:pubmed |
| pubmed-article:18701096 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18701096 | pubmed:articleTitle | Tumor suppressor gene insulin-like growth factor binding protein-related protein 1 (IGFBP-rP1) induces senescence-like growth arrest in colorectal cancer cells. | lld:pubmed |
| pubmed-article:18701096 | pubmed:affiliation | Department of Pathology, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310058, China. | lld:pubmed |
| pubmed-article:18701096 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18701096 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:3484 | entrezgene:pubmed | pubmed-article:18701096 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:18701096 | lld:entrezgene |
| lhgdn:association:13285 | lhgdn:found_in | pubmed-article:18701096 | lld:lhgdn |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:18701096 | lld:pubmed |
