| pubmed-article:1869831 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1869831 | lifeskim:mentions | umls-concept:C0021757 | lld:lifeskim |
| pubmed-article:1869831 | lifeskim:mentions | umls-concept:C0021758 | lld:lifeskim |
| pubmed-article:1869831 | lifeskim:mentions | umls-concept:C0024899 | lld:lifeskim |
| pubmed-article:1869831 | lifeskim:mentions | umls-concept:C0021853 | lld:lifeskim |
| pubmed-article:1869831 | lifeskim:mentions | umls-concept:C0003241 | lld:lifeskim |
| pubmed-article:1869831 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:1869831 | pubmed:dateCreated | 1991-9-16 | lld:pubmed |
| pubmed-article:1869831 | pubmed:abstractText | Rodents infected with the nematode parasite Nippostrongylus brasiliensis (Nb) develop intestinal mastocytosis, eosinophilia, and elevated serum IgE levels. Although IL-4 and IL-5 are necessary for stimulation of IgE synthesis and eosinophilia, respectively, the cytokines that regulate gut mast cell hyperplasia have not been identified. To address this question, 6- to 8-wk-old BALB/c mice were injected on day 0 and day 7 of Nb infection with a rat anti-mouse IL-4 mAb, and with polyclonal sheep (day 0) and rabbit (day 7) anti-mouse IL-3 IgG antibodies. Additional Nb-infected mice received equal doses of isotype- and species-matched control antibodies. Mice were sacrificed on days 12 or 13 post-infection, and mucosal mast cells (MMC) in sections of the small intestine were enumerated. Nb infection induced a 25- to 40-fold increase in MMC over that observed in uninfected controls. Anti-IL-3 or anti-IL-4 alone suppressed the Nb-induced MMC response by 40 to 50%, whereas both antibodies combined suppressed the MMC response by 85 to 90%. Anti-IL-3 alone had no effect on the serum IgE levels, which were essentially abrogated in the Nb-infected mice treated with anti-IL-4. Blood eosinophilia was not affected by treatment with anti-IL-3 and/or anti-IL-4. These studies demonstrate that IL-3 and IL-4 are physiologically important stimuli of mastocytosis in vivo, and suggest therapeutic interventions that may counteract adverse host responses to allergens as well as to parasites. | lld:pubmed |
| pubmed-article:1869831 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1869831 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1869831 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1869831 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:1869831 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:1869831 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1869831 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:1869831 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:1869831 | pubmed:author | pubmed-author:SchraderJ WJW | lld:pubmed |
| pubmed-article:1869831 | pubmed:author | pubmed-author:FinkelmanF... | lld:pubmed |
| pubmed-article:1869831 | pubmed:author | pubmed-author:UrbanJ FJFJr | lld:pubmed |
| pubmed-article:1869831 | pubmed:author | pubmed-author:ZiltenerH JHJ | lld:pubmed |
| pubmed-article:1869831 | pubmed:author | pubmed-author:KatonaI MIM | lld:pubmed |
| pubmed-article:1869831 | pubmed:author | pubmed-author:MaddenK BKB | lld:pubmed |
| pubmed-article:1869831 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1869831 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:1869831 | pubmed:volume | 147 | lld:pubmed |
| pubmed-article:1869831 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1869831 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1869831 | pubmed:pagination | 1387-91 | lld:pubmed |
| pubmed-article:1869831 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:1869831 | pubmed:meshHeading | pubmed-meshheading:1869831-... | lld:pubmed |
| pubmed-article:1869831 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1869831 | pubmed:articleTitle | Antibodies to IL-3 and IL-4 suppress helminth-induced intestinal mastocytosis. | lld:pubmed |
| pubmed-article:1869831 | pubmed:affiliation | Department of Pediatrics, F. Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814. | lld:pubmed |
| pubmed-article:1869831 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1869831 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:1869831 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:1869831 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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