| pubmed-article:18684981 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18684981 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:18684981 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:18684981 | lifeskim:mentions | umls-concept:C0020792 | lld:lifeskim |
| pubmed-article:18684981 | lifeskim:mentions | umls-concept:C0036536 | lld:lifeskim |
| pubmed-article:18684981 | lifeskim:mentions | umls-concept:C0383327 | lld:lifeskim |
| pubmed-article:18684981 | lifeskim:mentions | umls-concept:C0036537 | lld:lifeskim |
| pubmed-article:18684981 | lifeskim:mentions | umls-concept:C0036098 | lld:lifeskim |
| pubmed-article:18684981 | lifeskim:mentions | umls-concept:C2936411 | lld:lifeskim |
| pubmed-article:18684981 | lifeskim:mentions | umls-concept:C0079189 | lld:lifeskim |
| pubmed-article:18684981 | lifeskim:mentions | umls-concept:C0039082 | lld:lifeskim |
| pubmed-article:18684981 | lifeskim:mentions | umls-concept:C0333348 | lld:lifeskim |
| pubmed-article:18684981 | lifeskim:mentions | umls-concept:C1521871 | lld:lifeskim |
| pubmed-article:18684981 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:18684981 | pubmed:dateCreated | 2008-8-7 | lld:pubmed |
| pubmed-article:18684981 | pubmed:abstractText | IL-18 is a proinflammatory cytokine and plays an important pathogenic role in inflammatory and autoimmune disorders. IL-17 is also a proinflammatory cytokine and IL-17-secreting Th17 cells are involved in autoimmunity. However, the pathological roles of IL-18 and Th17 cells in Sjögren's syndrome (SS) remain to be elucidated. This study showed that the expression of IL-18 was detected in acinar cells, intraducts, and CD68(+) macrophages in salivary glands of SS patients, but not in those of healthy subjects or patients with chronic graft-vs-host disease, by immunohistochemistry, and immunoblot analysis revealed that 24-kDa precursor form of IL-18 (proIL-18) and 18-kDa mature IL-18 were detected in SS salivary glands. The majority of the infiltrating cells in the salivary glands of SS patients were CD4(+) T cells, and CD8(+) T cells were infiltrated to a lesser extent. The predominant expression of IL-17 was found in infiltrating CD4(+) T cells, whereas a small number of infiltrating CD8(+) T cells expressed IL-17. Human salivary gland HSY and acinar AZA3 cells constitutively expressed proIL-18 and caspase-1, and a calcium ionophore A23187 induced the secretion of IL-18 from the cells. HSY and AZA3 cells expressed IL-18R and IL-17R on the cell surface, and IL-18 amplified the secretion of IL-6 and IL-8 that were induced by low amounts of IL-17. Primary salivary gland cells from normal subjects partially confirmed these findings. These results suggest that IL-18 and Th17 cells detected in the salivary glands in SS patients are associated with the pathogenesis of SS in the salivary glands. | lld:pubmed |
| pubmed-article:18684981 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18684981 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18684981 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:18684981 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18684981 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18684981 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18684981 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18684981 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18684981 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:18684981 | pubmed:issn | 1550-6606 | lld:pubmed |
| pubmed-article:18684981 | pubmed:author | pubmed-author:SugawaraShunj... | lld:pubmed |
| pubmed-article:18684981 | pubmed:author | pubmed-author:KuroishiToshi... | lld:pubmed |
| pubmed-article:18684981 | pubmed:author | pubmed-author:SasanoTakashi... | lld:pubmed |
| pubmed-article:18684981 | pubmed:author | pubmed-author:SugawaraYumik... | lld:pubmed |
| pubmed-article:18684981 | pubmed:author | pubmed-author:SakaiAzusaA | lld:pubmed |
| pubmed-article:18684981 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18684981 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:18684981 | pubmed:volume | 181 | lld:pubmed |
| pubmed-article:18684981 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18684981 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18684981 | pubmed:pagination | 2898-906 | lld:pubmed |
| pubmed-article:18684981 | pubmed:meshHeading | pubmed-meshheading:18684981... | lld:pubmed |
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| pubmed-article:18684981 | pubmed:meshHeading | pubmed-meshheading:18684981... | lld:pubmed |
| pubmed-article:18684981 | pubmed:meshHeading | pubmed-meshheading:18684981... | lld:pubmed |
| pubmed-article:18684981 | pubmed:meshHeading | pubmed-meshheading:18684981... | lld:pubmed |
| pubmed-article:18684981 | pubmed:meshHeading | pubmed-meshheading:18684981... | lld:pubmed |
| pubmed-article:18684981 | pubmed:meshHeading | pubmed-meshheading:18684981... | lld:pubmed |
| pubmed-article:18684981 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18684981 | pubmed:articleTitle | Identification of IL-18 and Th17 cells in salivary glands of patients with Sjögren's syndrome, and amplification of IL-17-mediated secretion of inflammatory cytokines from salivary gland cells by IL-18. | lld:pubmed |
| pubmed-article:18684981 | pubmed:affiliation | Division of Oral Immunology, Department of Oral Biology, Tohoku University Graduate School of Dentistry, Sendai, Japan. | lld:pubmed |
| pubmed-article:18684981 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18684981 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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