| pubmed-article:18684087 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18684087 | lifeskim:mentions | umls-concept:C0816871 | lld:lifeskim |
| pubmed-article:18684087 | lifeskim:mentions | umls-concept:C0020626 | lld:lifeskim |
| pubmed-article:18684087 | lifeskim:mentions | umls-concept:C0678594 | lld:lifeskim |
| pubmed-article:18684087 | lifeskim:mentions | umls-concept:C0871161 | lld:lifeskim |
| pubmed-article:18684087 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:18684087 | pubmed:dateCreated | 2008-11-25 | lld:pubmed |
| pubmed-article:18684087 | pubmed:abstractText | Hypoparathyroidism, a disorder in which PTH is absent, is associated with BMD that is above average. We studied associated structural and dynamic properties of the skeleton in hypoparathyroidism. Thirty-three subjects with hypoparathyroidism and 33 age- and sex-matched control subjects with no known metabolic diseases underwent percutaneous iliac crest bone biopsies after double-labeling with tetracycline. The main outcome was histomorphometric assessment of structural and dynamic skeletal parameters. Subjects with hypoparathyroidism had greater cancellous bone volume (mean +/- SD; BV/TV: 23.5 +/- 8 versus 19.7 +/- 5%, p = 0.02), trabecular width (Tb.Wi: 136.1 +/- 37 versus 119.3 +/- 21 microm, p = 0.03), and cortical width (Ct.Wi: 923.4 +/- 420 versus 753.5 +/- 246 microm, p = 0.05) than control subjects. Dynamic skeletal indices, including mineralizing surface (MS: 0.85 +/- 1.58 versus 4.27 +/- 3.32%, p < 0.0001) and bone formation rate (BFR/BS: 0.006 +/- 0.014 versus 0.032 +/- 0.028 microm(3)/microm(2)/d, p < 0.0001), were profoundly suppressed in the hypoparathyroid subjects. We conclude that hypoparathyroidism is characterized by markedly unusual structural and dynamic properties of bone. | lld:pubmed |
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| pubmed-article:18684087 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18684087 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18684087 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18684087 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18684087 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:18684087 | pubmed:issn | 1523-4681 | lld:pubmed |
| pubmed-article:18684087 | pubmed:author | pubmed-author:BilezikianJoh... | lld:pubmed |
| pubmed-article:18684087 | pubmed:author | pubmed-author:RubinMishaela... | lld:pubmed |
| pubmed-article:18684087 | pubmed:author | pubmed-author:SilverbergSho... | lld:pubmed |
| pubmed-article:18684087 | pubmed:author | pubmed-author:ZhouHuaH | lld:pubmed |
| pubmed-article:18684087 | pubmed:author | pubmed-author:DempsterDavid... | lld:pubmed |
| pubmed-article:18684087 | pubmed:author | pubmed-author:ShaneElizabet... | lld:pubmed |
| pubmed-article:18684087 | pubmed:author | pubmed-author:NickolasThoma... | lld:pubmed |
| pubmed-article:18684087 | pubmed:author | pubmed-author:SlineyJamesJJ... | lld:pubmed |
| pubmed-article:18684087 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18684087 | pubmed:volume | 23 | lld:pubmed |
| pubmed-article:18684087 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18684087 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18684087 | pubmed:pagination | 2018-24 | lld:pubmed |
| pubmed-article:18684087 | pubmed:dateRevised | 2010-9-21 | lld:pubmed |
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| pubmed-article:18684087 | pubmed:meshHeading | pubmed-meshheading:18684087... | lld:pubmed |
| pubmed-article:18684087 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18684087 | pubmed:articleTitle | Dynamic and structural properties of the skeleton in hypoparathyroidism. | lld:pubmed |
| pubmed-article:18684087 | pubmed:affiliation | College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA. | lld:pubmed |
| pubmed-article:18684087 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18684087 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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