| pubmed-article:18681194 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18681194 | lifeskim:mentions | umls-concept:C0220847 | lld:lifeskim |
| pubmed-article:18681194 | lifeskim:mentions | umls-concept:C0021311 | lld:lifeskim |
| pubmed-article:18681194 | lifeskim:mentions | umls-concept:C0338666 | lld:lifeskim |
| pubmed-article:18681194 | lifeskim:mentions | umls-concept:C0277785 | lld:lifeskim |
| pubmed-article:18681194 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:18681194 | pubmed:dateCreated | 2008-8-6 | lld:pubmed |
| pubmed-article:18681194 | pubmed:abstractText | HCV and HIV infections are very common among injection drug users (IDUs). It is well known that 80-90% of HIV-infected IDUs are also infected with HCV. Furthermore, patients with HCV/HIV co-infection are at a higher risk of progressing to end-stage liver disease, namely cirrhosis. Even though there is increasing global awareness of HCV/HIV co-infection and extended therapeutic programs for this infected population, little is known about the HCV/HIV pathophysiology that mediates the rapid progression to hepatic disease. Liver disease caused by HCV/HIV co-infection is characterized by inflammation and cell-death. Recent reports suggest that the HIV and HCV envelope proteins may induce apoptosis and inflammation in hepatocytes via a novel pathway involving collaborative signaling. Moreover, HCV/HIV co-infection may also alter the cytokine production in vivo. Further studies to elucidate the molecular mechanisms of HCV and HIV-mediated pathogenesis will help in the development of therapeutic strategies against HCV/HIV co-infection in these patients. | lld:pubmed |
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| pubmed-article:18681194 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18681194 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18681194 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:18681194 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18681194 | pubmed:issn | 1055-0887 | lld:pubmed |
| pubmed-article:18681194 | pubmed:author | pubmed-author:GanjuRamesh... | lld:pubmed |
| pubmed-article:18681194 | pubmed:author | pubmed-author:GroopmanJerom... | lld:pubmed |
| pubmed-article:18681194 | pubmed:author | pubmed-author:Balasubramani... | lld:pubmed |
| pubmed-article:18681194 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18681194 | pubmed:volume | 27 | lld:pubmed |
| pubmed-article:18681194 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18681194 | pubmed:authorsComplete | Y | lld:pubmed |
