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pubmed-article:1868045pubmed:abstractTextInterleukin-2 (IL-2) plus lymphokine-activated killer (LAK) cell therapy has antineoplastic activity in renal cancer and malignant melanoma. In order to explore the activity of this therapy in Hodgkin's disease and non-Hodgkin's lymphoma, the Extramural IL-2/LAK Working Group (ILWG) treated 27 patients on two protocols using high-dose IL-2 and autologous LAK cells. Two of 12 patients with Hodgkin's disease experienced partial responses lasting 6 and 12 weeks. No patient with non-Hodgkin's lymphoma responded (p = NS). The toxicities of therapy were similar to those reported by the ILWG from trials of IL-2/LAK in solid tumors, consisting of transient hemodynamic, cardiopulmonary, renal and hepatic dysfunction, skin rash, fever, and flu-like symptoms. In view of the low response rate and the brief duration of these responses, we do not recommend the regimens reported here for further investigation in Hodgkin's disease or non-Hodgkin's lymphomas.lld:pubmed
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pubmed-article:1868045pubmed:authorpubmed-author:FisherR IRIlld:pubmed
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pubmed-article:1868045pubmed:pagination214-20lld:pubmed
pubmed-article:1868045pubmed:dateRevised2008-3-18lld:pubmed
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pubmed-article:1868045pubmed:articleTitlePhase II trial of high-dose interleukin-2 and lymphokine-activated killer cells in Hodgkin's disease and non-Hodgkin's lymphoma.lld:pubmed
pubmed-article:1868045pubmed:affiliationExtramural IL-2/LAK Working Group, City of Hope Cancer Research Center, Durate 91010.lld:pubmed
pubmed-article:1868045pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:1868045pubmed:publicationTypeClinical Triallld:pubmed
pubmed-article:1868045pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
pubmed-article:1868045pubmed:publicationTypeMulticenter Studylld:pubmed
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