| pubmed-article:18680140 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18680140 | lifeskim:mentions | umls-concept:C0001811 | lld:lifeskim |
| pubmed-article:18680140 | lifeskim:mentions | umls-concept:C0019564 | lld:lifeskim |
| pubmed-article:18680140 | lifeskim:mentions | umls-concept:C0700327 | lld:lifeskim |
| pubmed-article:18680140 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:18680140 | pubmed:dateCreated | 2008-12-29 | lld:pubmed |
| pubmed-article:18680140 | pubmed:abstractText | Rats use time-of-day cues to modulate learned taste aversion memories. If adult rats are accustomed to drinking saline in the evening and they receive a lithium chloride injection after drinking saline in the morning, they form a stronger aversion to saline than rats that were conditioned after drinking saline at the familiar time. The difference indicated that the rats formed segregated representations of saline taste and the time of day the saline was consumed. This was inferred because the modulation of learning by time of day was observed when the aversions were tested at the familiar evening drinking time. If the rats had formed a compound representation of saline taste and the time of day it was consumed, the opposite pattern of differences would be expected. We used this modulation of learning by time of day to assay whether aged rats have an impaired ability to form segregated representations of experience. We find that aged rats had similar saline aversions if they were conditioned at either the familiar or the unfamiliar time of day. Furthermore, dorsal hippocampal lesions affecting also the overlying parietal cortex in the aged rats caused greater saline aversions if the rats were conditioned after drinking saline at the familiar time of day. This indicated that aged rats are aware of the time of day but after the lesion, they act as if they do not segregate saline taste from the time of day it was consumed. The results suggest that the ability to form segregated representations of a complex experience is impaired in aging and abolished by hippocampal lesions. | lld:pubmed |
| pubmed-article:18680140 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18680140 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18680140 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18680140 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18680140 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18680140 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18680140 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:18680140 | pubmed:issn | 1098-1063 | lld:pubmed |
| pubmed-article:18680140 | pubmed:author | pubmed-author:MorónIgnacioI | lld:pubmed |
| pubmed-article:18680140 | pubmed:author | pubmed-author:ManriqueTatia... | lld:pubmed |
| pubmed-article:18680140 | pubmed:author | pubmed-author:GalloMilagros... | lld:pubmed |
| pubmed-article:18680140 | pubmed:author | pubmed-author:FentonAndré... | lld:pubmed |
| pubmed-article:18680140 | pubmed:author | pubmed-author:BallesterosMa... | lld:pubmed |
| pubmed-article:18680140 | pubmed:author | pubmed-author:GuerreroRosa... | lld:pubmed |
| pubmed-article:18680140 | pubmed:copyrightInfo | Copyright 2008 Wiley-Liss, Inc. | lld:pubmed |
| pubmed-article:18680140 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18680140 | pubmed:volume | 19 | lld:pubmed |
| pubmed-article:18680140 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18680140 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18680140 | pubmed:pagination | 57-65 | lld:pubmed |
| pubmed-article:18680140 | pubmed:dateRevised | 2009-3-2 | lld:pubmed |
| pubmed-article:18680140 | pubmed:meshHeading | pubmed-meshheading:18680140... | lld:pubmed |
| pubmed-article:18680140 | pubmed:meshHeading | pubmed-meshheading:18680140... | lld:pubmed |
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| pubmed-article:18680140 | pubmed:meshHeading | pubmed-meshheading:18680140... | lld:pubmed |
| pubmed-article:18680140 | pubmed:meshHeading | pubmed-meshheading:18680140... | lld:pubmed |
| pubmed-article:18680140 | pubmed:meshHeading | pubmed-meshheading:18680140... | lld:pubmed |
| pubmed-article:18680140 | pubmed:meshHeading | pubmed-meshheading:18680140... | lld:pubmed |
| pubmed-article:18680140 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:18680140 | pubmed:articleTitle | Hippocampus, aging, and segregating memories. | lld:pubmed |
| pubmed-article:18680140 | pubmed:affiliation | Institute of Neurosciences F. Oloriz, University of Granada, Spain. | lld:pubmed |
| pubmed-article:18680140 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18680140 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
