| pubmed-article:18679800 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18679800 | lifeskim:mentions | umls-concept:C0021102 | lld:lifeskim |
| pubmed-article:18679800 | lifeskim:mentions | umls-concept:C0872312 | lld:lifeskim |
| pubmed-article:18679800 | lifeskim:mentions | umls-concept:C0596177 | lld:lifeskim |
| pubmed-article:18679800 | lifeskim:mentions | umls-concept:C0600364 | lld:lifeskim |
| pubmed-article:18679800 | lifeskim:mentions | umls-concept:C1704229 | lld:lifeskim |
| pubmed-article:18679800 | lifeskim:mentions | umls-concept:C1705604 | lld:lifeskim |
| pubmed-article:18679800 | lifeskim:mentions | umls-concept:C0600484 | lld:lifeskim |
| pubmed-article:18679800 | lifeskim:mentions | umls-concept:C0013812 | lld:lifeskim |
| pubmed-article:18679800 | lifeskim:mentions | umls-concept:C1510941 | lld:lifeskim |
| pubmed-article:18679800 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:18679800 | lifeskim:mentions | umls-concept:C0047006 | lld:lifeskim |
| pubmed-article:18679800 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:18679800 | pubmed:dateCreated | 2009-2-5 | lld:pubmed |
| pubmed-article:18679800 | pubmed:abstractText | Our interest is in the development of engineered microdevices for continuous remote monitoring of intramuscular lactate, glucose, pH and temperature during post-traumatic hemorrhaging. Two important design considerations in the development of such devices for in vivo diagnostics are discussed; the utility of micro-disc electrode arrays (MDEAs) for electrochemical biosensing and the application of biomimetic, bioactive poly(HEMA)-based hydrogel composites for implant biocompatibility. A poly(HEMA)-based hydrogel membrane containing polyethylene glycol (PEG) was UV cross-linked with tetraethyleneglycol diacrylate following application to MDEAs (50 mum discs) and to 250 mum diameter gold electrodes within 8-well culture ware. Cyclic voltammetry (CV) of the MDEAs revealed a reduction in the apparent diffusion coefficient of ferrocenemonocarboxylic acid (FcCO(2)H), from 6.68 x 10(-5) to 6.74 x 10(-6) cm(2)/s for the uncoated and 6 mum thick hydrogel coated devices, respectively. Single frequency (4 kHz) temporal impedance measurements of the hydrogels in the 8-well culture ware showed a reversible 5% change in the absolute impedance of the hydrogels when exposed to a pH change between 6.1 to 7.2 and a 20% drop between pH 6.1 and 8.8. | lld:pubmed |
| pubmed-article:18679800 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18679800 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18679800 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18679800 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18679800 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18679800 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18679800 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18679800 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18679800 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18679800 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:18679800 | pubmed:issn | 1572-8781 | lld:pubmed |
| pubmed-article:18679800 | pubmed:author | pubmed-author:Guiseppi-Elie... | lld:pubmed |
| pubmed-article:18679800 | pubmed:author | pubmed-author:JustinGusphyl... | lld:pubmed |
| pubmed-article:18679800 | pubmed:author | pubmed-author:Abdur... | lld:pubmed |
| pubmed-article:18679800 | pubmed:author | pubmed-author:FinleyStephen... | lld:pubmed |
| pubmed-article:18679800 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18679800 | pubmed:volume | 11 | lld:pubmed |
| pubmed-article:18679800 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18679800 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18679800 | pubmed:pagination | 103-15 | lld:pubmed |
| pubmed-article:18679800 | pubmed:meshHeading | pubmed-meshheading:18679800... | lld:pubmed |
| pubmed-article:18679800 | pubmed:meshHeading | pubmed-meshheading:18679800... | lld:pubmed |
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| pubmed-article:18679800 | pubmed:meshHeading | pubmed-meshheading:18679800... | lld:pubmed |
| pubmed-article:18679800 | pubmed:meshHeading | pubmed-meshheading:18679800... | lld:pubmed |
| pubmed-article:18679800 | pubmed:meshHeading | pubmed-meshheading:18679800... | lld:pubmed |
| pubmed-article:18679800 | pubmed:meshHeading | pubmed-meshheading:18679800... | lld:pubmed |
| pubmed-article:18679800 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:18679800 | pubmed:articleTitle | Biomimetic hydrogels for biosensor implant biocompatibility: electrochemical characterization using micro-disc electrode arrays (MDEAs). | lld:pubmed |
| pubmed-article:18679800 | pubmed:affiliation | Center for Bioelectronics, Biosensors and Biochips (C3B), Clemson University Advanced Materials Center, 100 Technology Drive, Anderson, SC 29625, USA. gusphyl@clemson.edu | lld:pubmed |
| pubmed-article:18679800 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18679800 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
