| pubmed-article:18664516 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18664516 | lifeskim:mentions | umls-concept:C0684336 | lld:lifeskim |
| pubmed-article:18664516 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:18664516 | lifeskim:mentions | umls-concept:C1527304 | lld:lifeskim |
| pubmed-article:18664516 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:18664516 | pubmed:dateCreated | 2008-9-19 | lld:pubmed |
| pubmed-article:18664516 | pubmed:abstractText | Gads is a Grb2-like adaptor protein expressed in hematopoietic cells. We demonstrated that mast cells from Gads(-/-) mice have selective functional defects. Bone marrow-derived mast cells from Gads(-/-) mice failed to induce Ca(2+) mobilization, degranulation and cytokine production upon cross-linking of FcepsilonRI. In vivo passive cutaneous anaphylaxis was also greatly impaired in Gads(-/-) mice. In contrast, Gads was dispensable for Toll-like receptor-mediated cytokine production in mast cells. Accordingly, mast cell-dependent resistance to acute peritoneal bacterial infection is not reduced in Gads(-/-) mice in vivo. Moreover, mature T and B cell responses and antibody production upon immunization were apparently normal in Gads(-/-) mice. Thus, inhibition of Gads in vivo would suppress the IgE-mediated allergic reaction with minimum adverse effects on both innate and acquired immune responses, and Gads could be an ideal target for the control of allergic responses. | lld:pubmed |
| pubmed-article:18664516 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18664516 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18664516 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18664516 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18664516 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18664516 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18664516 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18664516 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18664516 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18664516 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:18664516 | pubmed:issn | 1460-2377 | lld:pubmed |
| pubmed-article:18664516 | pubmed:author | pubmed-author:YamasakiShoS | lld:pubmed |
| pubmed-article:18664516 | pubmed:author | pubmed-author:SaitoTakashiT | lld:pubmed |
| pubmed-article:18664516 | pubmed:author | pubmed-author:KanagawaOsami... | lld:pubmed |
| pubmed-article:18664516 | pubmed:author | pubmed-author:NishidaKeigoK | lld:pubmed |
| pubmed-article:18664516 | pubmed:author | pubmed-author:SakumaMachieM | lld:pubmed |
| pubmed-article:18664516 | pubmed:author | pubmed-author:IshikawaEriE | lld:pubmed |
| pubmed-article:18664516 | pubmed:author | pubmed-author:Takase-Utsugi... | lld:pubmed |
| pubmed-article:18664516 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18664516 | pubmed:volume | 20 | lld:pubmed |
| pubmed-article:18664516 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18664516 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18664516 | pubmed:pagination | 1289-97 | lld:pubmed |
| pubmed-article:18664516 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:18664516 | pubmed:meshHeading | pubmed-meshheading:18664516... | lld:pubmed |
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| pubmed-article:18664516 | pubmed:meshHeading | pubmed-meshheading:18664516... | lld:pubmed |
| pubmed-article:18664516 | pubmed:meshHeading | pubmed-meshheading:18664516... | lld:pubmed |
| pubmed-article:18664516 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18664516 | pubmed:articleTitle | Selective impairment of FcepsilonRI-mediated allergic reaction in Gads-deficient mice. | lld:pubmed |
| pubmed-article:18664516 | pubmed:affiliation | Laboratory for Cell Signaling, RIKEN Research Center for Allergy and Immunology, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan. | lld:pubmed |
| pubmed-article:18664516 | pubmed:publicationType | Journal Article | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:18664516 | lld:pubmed |
