Linked Life Data

18656371

Source:http://linkedlifedata.com/resource/pubmed/id/18656371

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pubmed-article:18656371pubmed:abstractTextA series of drug-like compounds derived from Sildenafil, Vardenafil and Tadalafil analogues were modelled through the MIA-QSAR (multivariate image analysis applied to quantitative structure-activity relationships) ligand-based approach. A highly predictive model was achieved and novel compounds, miscellany of substructures of these three representative phosphodiesterase type-5 (PDE-5) inhibitors were predicted using the calibration parameters obtained through partial least squares (PLS) regression. The high bioactivities of eight promising compounds were corroborated by docking evaluation. Calculated ADME-Tox (absorption, distribution, metabolism, excretion and toxicity) profiles for such compounds suggest advantages of some of them over the currently available, most common drugs used for the treatment of erectile dysfunction.lld:pubmed
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pubmed-article:18656371pubmed:dateRevised2010-11-18lld:pubmed
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pubmed-article:18656371pubmed:articleTitleIn silico prediction of novel phosphodiesterase type-5 inhibitors derived from Sildenafil, Vardenafil and Tadalafil.lld:pubmed
pubmed-article:18656371pubmed:affiliationDepartamento de Química, Universidade Federal de Lavras-UFLA, CP 3037, 37200-000 Lavras, MG, Brazil.lld:pubmed
pubmed-article:18656371pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:18656371pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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