| pubmed-article:18648071 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18648071 | lifeskim:mentions | umls-concept:C0678662 | lld:lifeskim |
| pubmed-article:18648071 | lifeskim:mentions | umls-concept:C0035552 | lld:lifeskim |
| pubmed-article:18648071 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:18648071 | lifeskim:mentions | umls-concept:C0029073 | lld:lifeskim |
| pubmed-article:18648071 | lifeskim:mentions | umls-concept:C2587213 | lld:lifeskim |
| pubmed-article:18648071 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:18648071 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:18648071 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:18648071 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:18648071 | pubmed:dateCreated | 2008-8-29 | lld:pubmed |
| pubmed-article:18648071 | pubmed:abstractText | Autogenous regulation is a general strategy of balancing ribosomal protein synthesis in bacteria. Control mechanisms have been studied in detail for most of ribosomal protein operons, except for rpsB-tsf encoding essential r-protein S2 and elongation factor Ts, where even the promoter has remained unknown. By using single-copy translational fusions with the chromosomal lacZ gene and Western-blot analysis, we demonstrate here that S2 serves as a negative regulator of both rpsB and tsf expression in vivo, acting at a single target within the rpsB 5'-untranslated region (5'-UTR). As determined by primer extension, transcription of the Escherichia coli rpsB-tsf operon starts 162 nucleotides upstream of the rpsB initiation codon at a single promoter TGTGGTATAAA belonging to the extended -10 promoter class. Both the promoter signature and the 5'-UTR structure of the rpsB gene appear to be highly conserved in gamma-proteobacteria. Deletion analysis of the rpsB 5'-UTR within rpsB'-'lacZ fusions has revealed that an operator region involved in the S2 autoregulation comprises conserved structural elements located upstream of the rpsB ribosome binding site. The S2-mediated autogenous control is impaired in rpsB mutants and, more surprisingly, in the rpsA mutant producing decreased amounts of truncated r-protein S1 (rpsAIS10), indicating that S2 might act as a repressor in cooperation with S1. | lld:pubmed |
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| pubmed-article:18648071 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18648071 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18648071 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18648071 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:18648071 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18648071 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:18648071 | pubmed:issn | 1469-9001 | lld:pubmed |
| pubmed-article:18648071 | pubmed:author | pubmed-author:TchufistovaLu... | lld:pubmed |
| pubmed-article:18648071 | pubmed:author | pubmed-author:BoniIrina VIV | lld:pubmed |
| pubmed-article:18648071 | pubmed:author | pubmed-author:AseevLeonid... | lld:pubmed |
| pubmed-article:18648071 | pubmed:author | pubmed-author:Levandovskaya... | lld:pubmed |
| pubmed-article:18648071 | pubmed:author | pubmed-author:ScaptsovaNade... | lld:pubmed |
| pubmed-article:18648071 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18648071 | pubmed:volume | 14 | lld:pubmed |
| pubmed-article:18648071 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18648071 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18648071 | pubmed:pagination | 1882-94 | lld:pubmed |
| pubmed-article:18648071 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:18648071 | pubmed:meshHeading | pubmed-meshheading:18648071... | lld:pubmed |
| pubmed-article:18648071 | pubmed:meshHeading | pubmed-meshheading:18648071... | lld:pubmed |
| pubmed-article:18648071 | pubmed:meshHeading | pubmed-meshheading:18648071... | lld:pubmed |
| pubmed-article:18648071 | pubmed:meshHeading | pubmed-meshheading:18648071... | lld:pubmed |
