| pubmed-article:18644996 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18644996 | lifeskim:mentions | umls-concept:C0376358 | lld:lifeskim |
| pubmed-article:18644996 | lifeskim:mentions | umls-concept:C0599779 | lld:lifeskim |
| pubmed-article:18644996 | lifeskim:mentions | umls-concept:C0334227 | lld:lifeskim |
| pubmed-article:18644996 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:18644996 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:18644996 | lifeskim:mentions | umls-concept:C0897751 | lld:lifeskim |
| pubmed-article:18644996 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:18644996 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:18644996 | pubmed:dateCreated | 2008-7-22 | lld:pubmed |
| pubmed-article:18644996 | pubmed:abstractText | We have previously reported that, in prostate cancer, inhibition of the oncogenic sphingosine kinase-1/sphingosine 1-phosphate (SphK1/S1P) pathway is a key element in chemotherapy-induced apoptosis. Here, we show that selective pharmacologic inhibition of SphK1 triggers apoptosis in LNCaP and PC-3 prostate cancer cells, an effect that is reversed by SphK1 enforced expression. More importantly, we show for the first time that the up-regulation of the SphK1/S1P pathway plays a crucial role in the resistance of prostate cancer cells to chemotherapy. Importantly, pharmacologic SphK1 inhibition with the B-5354c compound sensitizes LNCaP and PC-3 cells to docetaxel and camptothecin, respectively. In vivo, camptothecin and B-5354c alone display a limited effect on tumor growth in PC-3 cells, whereas in combination there is a synergy of effect on tumor size with a significant increase in the ceramide to S1P sphingolipid ratio. To conclude, our study highlights the notion that drugs specifically designed to inhibit SphK1 could provide a means of enhancing the effects of conventional treatment through the prosurvival antiapoptotic SphK1/S1P pathway. | lld:pubmed |
| pubmed-article:18644996 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18644996 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18644996 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18644996 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:18644996 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18644996 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:18644996 | pubmed:issn | 1535-7163 | lld:pubmed |
| pubmed-article:18644996 | pubmed:author | pubmed-author:WaxmanJonatha... | lld:pubmed |
| pubmed-article:18644996 | pubmed:author | pubmed-author:GolzioMurielM | lld:pubmed |
| pubmed-article:18644996 | pubmed:author | pubmed-author:KohamaTakafum... | lld:pubmed |
| pubmed-article:18644996 | pubmed:author | pubmed-author:TeissiéJustin... | lld:pubmed |
| pubmed-article:18644996 | pubmed:author | pubmed-author:CuvillierOliv... | lld:pubmed |
| pubmed-article:18644996 | pubmed:author | pubmed-author:PchejetskiDim... | lld:pubmed |
| pubmed-article:18644996 | pubmed:author | pubmed-author:MalavaudBerna... | lld:pubmed |
| pubmed-article:18644996 | pubmed:author | pubmed-author:DoumercNicola... | lld:pubmed |
| pubmed-article:18644996 | pubmed:author | pubmed-author:NaymarkMariaM | lld:pubmed |
| pubmed-article:18644996 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18644996 | pubmed:volume | 7 | lld:pubmed |
| pubmed-article:18644996 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18644996 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18644996 | pubmed:pagination | 1836-45 | lld:pubmed |
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| pubmed-article:18644996 | pubmed:meshHeading | pubmed-meshheading:18644996... | lld:pubmed |
| pubmed-article:18644996 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18644996 | pubmed:articleTitle | Chemosensitizing effects of sphingosine kinase-1 inhibition in prostate cancer cell and animal models. | lld:pubmed |
| pubmed-article:18644996 | pubmed:affiliation | Centre National de la Recherche Scientifique, Institut de Pharmacologie et de Biologie Structurale, UMR 5089, 31077 Toulouse Cedex 4, France. | lld:pubmed |
| pubmed-article:18644996 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18644996 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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