| pubmed-article:18641319 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18641319 | lifeskim:mentions | umls-concept:C0025260 | lld:lifeskim |
| pubmed-article:18641319 | lifeskim:mentions | umls-concept:C1332717 | lld:lifeskim |
| pubmed-article:18641319 | lifeskim:mentions | umls-concept:C1706438 | lld:lifeskim |
| pubmed-article:18641319 | lifeskim:mentions | umls-concept:C0024204 | lld:lifeskim |
| pubmed-article:18641319 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:18641319 | lifeskim:mentions | umls-concept:C0085358 | lld:lifeskim |
| pubmed-article:18641319 | lifeskim:mentions | umls-concept:C1521970 | lld:lifeskim |
| pubmed-article:18641319 | lifeskim:mentions | umls-concept:C1413244 | lld:lifeskim |
| pubmed-article:18641319 | lifeskim:mentions | umls-concept:C2698600 | lld:lifeskim |
| pubmed-article:18641319 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:18641319 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:18641319 | pubmed:dateCreated | 2008-7-21 | lld:pubmed |
| pubmed-article:18641319 | pubmed:abstractText | Exogenous dendritic cells display restricted trafficking when injected in vivo and stimulate CD8 T cell responses that are localized to a small number of lymphoid compartments. By examining these responses in the presence and absence of FTY720, a drug that causes sequestration of T cells in lymph nodes, we demonstrate that a significant fraction of divided CD8 T cells redistribute into Ag-free lymph nodes within 3 days of activation. Despite variation in the level of expression of CD62L, redistribution of these cells is CD62L-dependent. Redistributed CD8 T cells exhibit characteristics of differentiated effectors. However, when re-isolated from Ag-free lymph nodes 3 days after activation and transferred into naive mice, they persist for at least 3 wk and expand upon Ag challenge. Thus, CD8 T cells that redistribute to Ag-free lymph nodes 3 days after immunization contain memory precursors. We suggest that this redistribution process represents an important mechanism for establishment of lymph node resident central memory, and that redistribution to Ag-free nodes is an additional characteristic to be added to those that distinguish memory precursors from terminal effectors. | lld:pubmed |
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| pubmed-article:18641319 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18641319 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18641319 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:18641319 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18641319 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:18641319 | pubmed:issn | 1550-6606 | lld:pubmed |
| pubmed-article:18641319 | pubmed:author | pubmed-author:EngelhardVict... | lld:pubmed |
| pubmed-article:18641319 | pubmed:author | pubmed-author:FergusonAndre... | lld:pubmed |
| pubmed-article:18641319 | pubmed:author | pubmed-author:BrinkmanC... | lld:pubmed |
| pubmed-article:18641319 | pubmed:author | pubmed-author:Sheasley-O'Ne... | lld:pubmed |
| pubmed-article:18641319 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18641319 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:18641319 | pubmed:volume | 181 | lld:pubmed |
| pubmed-article:18641319 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18641319 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18641319 | pubmed:pagination | 1814-24 | lld:pubmed |
| pubmed-article:18641319 | pubmed:dateRevised | 2010-8-9 | lld:pubmed |
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| pubmed-article:18641319 | pubmed:meshHeading | pubmed-meshheading:18641319... | lld:pubmed |
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| pubmed-article:18641319 | pubmed:meshHeading | pubmed-meshheading:18641319... | lld:pubmed |
