| pubmed-article:18639367 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18639367 | lifeskim:mentions | umls-concept:C0035647 | lld:lifeskim |
| pubmed-article:18639367 | lifeskim:mentions | umls-concept:C0338656 | lld:lifeskim |
| pubmed-article:18639367 | lifeskim:mentions | umls-concept:C1882417 | lld:lifeskim |
| pubmed-article:18639367 | lifeskim:mentions | umls-concept:C0023981 | lld:lifeskim |
| pubmed-article:18639367 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:18639367 | pubmed:dateCreated | 2010-3-19 | lld:pubmed |
| pubmed-article:18639367 | pubmed:abstractText | The Pro12Ala polymorphism in the PPAR-gamma gene has been associated with reduced incidence of type 2 diabetes. Although diabetes has been implicated as a risk factor for dementia, the association of Pro12Ala with cognitive impairment is unclear. Dementia and cognitive impairment without dementia (CIND) were determined during six annual follow-up evaluations in a cohort of 929 older Latinos. Among those with diabetes at baseline, there was an increased rate of dementia/CIND for Ala carriers compared to non-carriers (adjusted hazard ratio (HR)=2.5, 95% confidence interval (CI): 1.3-4.9) but not among non-diabetic participants (adjusted HR=0.94; 95% CI: 0.49-1.8). Among males, there was also an increased rate for Ala carriers (adjusted HR=2.7, 95% CI: 1.4-5.2) but not among female carriers (adjusted HR=0.88; 95% CI: 0.47-1.6). The rate of dementia/CIND was highest in diabetic male Ala carriers (adjusted HR=4.2; 95% CI: 1.5-11) compared to non-diabetic male carriers (adjusted HR=2.9; 95% CI: 1.1-7.4), diabetic female carriers (HR=1.6; 95% CI: 0.66-4.1), and non-diabetic female carriers (HR=0.52; 95% CI: 0.21-1.3). These data suggest that although the Ala variant is associated with a reduced risk of type 2 diabetes, it may increase the risk of cognitive impairment in individuals once diabetes has developed. Male Ala carriers may also have a greater risk of dementia/CIND. | lld:pubmed |
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| pubmed-article:18639367 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18639367 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18639367 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:18639367 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18639367 | pubmed:month | May | lld:pubmed |
| pubmed-article:18639367 | pubmed:issn | 1558-1497 | lld:pubmed |
| pubmed-article:18639367 | pubmed:author | pubmed-author:MorgensternHa... | lld:pubmed |
| pubmed-article:18639367 | pubmed:author | pubmed-author:HaanMary NMN | lld:pubmed |
| pubmed-article:18639367 | pubmed:author | pubmed-author:WestNancy ANA | lld:pubmed |
| pubmed-article:18639367 | pubmed:copyrightInfo | (c) 2008 Elsevier Inc. All rights reserved. | lld:pubmed |
| pubmed-article:18639367 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18639367 | pubmed:volume | 31 | lld:pubmed |
| pubmed-article:18639367 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18639367 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18639367 | pubmed:pagination | 741-6 | lld:pubmed |
| pubmed-article:18639367 | pubmed:dateRevised | 2011-7-28 | lld:pubmed |
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| pubmed-article:18639367 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:18639367 | pubmed:articleTitle | The PPAR-gamma Pro12Ala polymorphism and risk of cognitive impairment in a longitudinal study. | lld:pubmed |
| pubmed-article:18639367 | pubmed:affiliation | Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI 48109, USA. Nancy.West@uchsc.edu | lld:pubmed |
| pubmed-article:18639367 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18639367 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:18639367 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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