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pubmed-article:18638528pubmed:abstractTextMutation in UCH-L1 has been reported as a rare cause of autosomal dominant Parkinson's disease (PD). A S18Y polymorphism in the same gene has been associated with sporadic PD. We investigated the frequency of this polymorphism among the Han-Chinese ethnic population in a case-control study. A total of 600 patients with PD and 334 unrelated healthy controls were genotyped using PCR-restriction fragment length polymorphism analysis. We did not observe any difference in allele or genotype frequencies between the cases and the controls (P>0.05). Our results do not support a role for this variant in sporadic PD.lld:pubmed
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pubmed-article:18638528pubmed:articleTitleLack of evidence for association of a UCH-L1 S18Y polymorphism with Parkinson's disease in a Han-Chinese population.lld:pubmed
pubmed-article:18638528pubmed:affiliationDepartment of Neurology, West China Hospital, Sichuan University, Chengdu 610041, Chengdu, China.lld:pubmed
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