In vivo imaging of the inflammatory receptor CD40 after cerebral ischemia using a fluorescent antibody.

Source:http://linkedlifedata.com/resource/pubmed/id/18635859

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Authors

Harms C, Lindauer U, Dirnagl U, Dietrich T, Graf K, Wunder A, Gräfe M, Stelzer EH, Endres M, Steinbrink J, Stibenz D, Kronenberg G, Klohs J, Bahmani P, Greger K

Affiliation

Department Experimental Neurology, Charité-University Medicine Berlin, Berlin, Germany. jan.klohs@charite.de

Abstract

Brain inflammation is a hallmark of stroke, where it has been implicated in tissue damage as well as in repair. Imaging technologies that specifically visualize these processes are highly desirable. In this study, we explored whether the inflammatory receptor CD40 can be noninvasively and specifically visualized in mice after cerebral ischemia using a fluorescent monoclonal antibody, which we labeled with the near-infrared fluorescence dye Cy5.5 (Cy5.5-CD40MAb).

PMID
18635859

Publication types

Research Support, Non-U.S. Gov't