| pubmed-article:1863557 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1863557 | lifeskim:mentions | umls-concept:C0015576 | lld:lifeskim |
| pubmed-article:1863557 | lifeskim:mentions | umls-concept:C0680022 | lld:lifeskim |
| pubmed-article:1863557 | lifeskim:mentions | umls-concept:C0013935 | lld:lifeskim |
| pubmed-article:1863557 | lifeskim:mentions | umls-concept:C0043343 | lld:lifeskim |
| pubmed-article:1863557 | lifeskim:mentions | umls-concept:C0025485 | lld:lifeskim |
| pubmed-article:1863557 | lifeskim:mentions | umls-concept:C0040690 | lld:lifeskim |
| pubmed-article:1863557 | lifeskim:mentions | umls-concept:C0530979 | lld:lifeskim |
| pubmed-article:1863557 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:1863557 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:1863557 | lifeskim:mentions | umls-concept:C0936012 | lld:lifeskim |
| pubmed-article:1863557 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:1863557 | pubmed:dateCreated | 1991-9-11 | lld:pubmed |
| pubmed-article:1863557 | pubmed:abstractText | We have screened a Xenopus ovary cDNA library using a synthetic oligonucleotide derived from that part of the inhibin beta A sequence, which is highly conserved within the TGF-beta family. Out of several clones yielding autoradiographic signals four turned out to represent Xenopus counterparts to the human bone morphogenetic protein 4 (BMP-4). Each two of the four sequences are nearly identical and probably account for different alleles whereas the two pairs showing 5% divergence may have arisen by genome duplication in this tetraploid species. The amino acid sequence of the Xenopus protein is 80% homologous to the human sequence showing no single exchange within the last 100 amino acids at the C-terminus. This region, which constitutes the main part of the mature, biologically active protein, also exhibits substantial homologies to other representatives of the TGF-beta family, especially to the Drosophila DPPC protein. Transfection of COS-1 cells with the Xenopus BMP-4 sequence under control of the CMV-promoter leads to the secretion of a protein which exhibits mesoderm inducing activity when tested with animal cap explants from Xenopus blastula stage embryos. | lld:pubmed |
| pubmed-article:1863557 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1863557 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1863557 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1863557 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1863557 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:1863557 | pubmed:issn | 0925-4773 | lld:pubmed |
| pubmed-article:1863557 | pubmed:author | pubmed-author:TiedemannHH | lld:pubmed |
| pubmed-article:1863557 | pubmed:author | pubmed-author:KnöchelWW | lld:pubmed |
| pubmed-article:1863557 | pubmed:author | pubmed-author:LorenzAA | lld:pubmed |
| pubmed-article:1863557 | pubmed:author | pubmed-author:KösterMM | lld:pubmed |
| pubmed-article:1863557 | pubmed:author | pubmed-author:ClemensJ GJG | lld:pubmed |
| pubmed-article:1863557 | pubmed:author | pubmed-author:PlessowSS | lld:pubmed |
| pubmed-article:1863557 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1863557 | pubmed:volume | 33 | lld:pubmed |
| pubmed-article:1863557 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1863557 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1863557 | pubmed:pagination | 191-9 | lld:pubmed |
| pubmed-article:1863557 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:1863557 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1863557 | pubmed:articleTitle | Bone morphogenetic protein 4 (BMP-4), a member of the TGF-beta family, in early embryos of Xenopus laevis: analysis of mesoderm inducing activity. | lld:pubmed |
| pubmed-article:1863557 | pubmed:affiliation | Department of Biochemistry, University of Ulm, F.R.G. | lld:pubmed |
| pubmed-article:1863557 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1863557 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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