| pubmed-article:18633409 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18633409 | lifeskim:mentions | umls-concept:C0007586 | lld:lifeskim |
| pubmed-article:18633409 | lifeskim:mentions | umls-concept:C0079183 | lld:lifeskim |
| pubmed-article:18633409 | lifeskim:mentions | umls-concept:C1446409 | lld:lifeskim |
| pubmed-article:18633409 | lifeskim:mentions | umls-concept:C0015744 | lld:lifeskim |
| pubmed-article:18633409 | lifeskim:mentions | umls-concept:C2911691 | lld:lifeskim |
| pubmed-article:18633409 | lifeskim:mentions | umls-concept:C0218063 | lld:lifeskim |
| pubmed-article:18633409 | lifeskim:mentions | umls-concept:C1550548 | lld:lifeskim |
| pubmed-article:18633409 | lifeskim:mentions | umls-concept:C1555714 | lld:lifeskim |
| pubmed-article:18633409 | lifeskim:mentions | umls-concept:C1705654 | lld:lifeskim |
| pubmed-article:18633409 | pubmed:issue | 7202 | lld:pubmed |
| pubmed-article:18633409 | pubmed:dateCreated | 2008-7-17 | lld:pubmed |
| pubmed-article:18633409 | pubmed:abstractText | In budding yeast, Saccharomyces cerevisiae, the Start checkpoint integrates multiple internal and external signals into an all-or-none decision to enter the cell cycle. Here we show that Start behaves like a switch due to systems-level feedback in the regulatory network. In contrast to current models proposing a linear cascade of Start activation, transcriptional positive feedback of the G1 cyclins Cln1 and Cln2 induces the near-simultaneous expression of the approximately 200-gene G1/S regulon. Nuclear Cln2 drives coherent regulon expression, whereas cytoplasmic Cln2 drives efficient budding. Cells with the CLN1 and CLN2 genes deleted frequently arrest as unbudded cells, incurring a large fluctuation-induced fitness penalty due to both the lack of cytoplasmic Cln2 and insufficient G1/S regulon expression. Thus, positive-feedback-amplified expression of Cln1 and Cln2 simultaneously drives robust budding and rapid, coherent regulon expression. A similar G1/S regulatory network in mammalian cells, comprised of non-orthologous genes, suggests either conservation of regulatory architecture or convergent evolution. | lld:pubmed |
| pubmed-article:18633409 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18633409 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18633409 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18633409 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18633409 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18633409 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18633409 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18633409 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18633409 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18633409 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18633409 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18633409 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18633409 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18633409 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18633409 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18633409 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18633409 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18633409 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18633409 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18633409 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18633409 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18633409 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18633409 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18633409 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18633409 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18633409 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18633409 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18633409 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18633409 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18633409 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18633409 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18633409 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18633409 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18633409 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18633409 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18633409 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18633409 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18633409 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18633409 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18633409 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18633409 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18633409 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18633409 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18633409 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18633409 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18633409 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18633409 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18633409 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18633409 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18633409 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18633409 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18633409 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18633409 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18633409 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18633409 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18633409 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18633409 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18633409 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18633409 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18633409 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:18633409 | pubmed:issn | 1476-4687 | lld:pubmed |
| pubmed-article:18633409 | pubmed:author | pubmed-author:CrossFrederic... | lld:pubmed |
| pubmed-article:18633409 | pubmed:author | pubmed-author:SiggiaEric... | lld:pubmed |
| pubmed-article:18633409 | pubmed:author | pubmed-author:SkotheimJan... | lld:pubmed |
| pubmed-article:18633409 | pubmed:author | pubmed-author:Di... | lld:pubmed |
| pubmed-article:18633409 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18633409 | pubmed:day | 17 | lld:pubmed |
| pubmed-article:18633409 | pubmed:volume | 454 | lld:pubmed |
| pubmed-article:18633409 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18633409 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18633409 | pubmed:pagination | 291-6 | lld:pubmed |
| pubmed-article:18633409 | pubmed:dateRevised | 2011-9-26 | lld:pubmed |
| pubmed-article:18633409 | pubmed:meshHeading | pubmed-meshheading:18633409... | lld:pubmed |
| pubmed-article:18633409 | pubmed:meshHeading | pubmed-meshheading:18633409... | lld:pubmed |
| pubmed-article:18633409 | pubmed:meshHeading | pubmed-meshheading:18633409... | lld:pubmed |
| pubmed-article:18633409 | pubmed:meshHeading | pubmed-meshheading:18633409... | lld:pubmed |
| pubmed-article:18633409 | pubmed:meshHeading | pubmed-meshheading:18633409... | lld:pubmed |
| pubmed-article:18633409 | pubmed:meshHeading | pubmed-meshheading:18633409... | lld:pubmed |
| pubmed-article:18633409 | pubmed:meshHeading | pubmed-meshheading:18633409... | lld:pubmed |
| pubmed-article:18633409 | pubmed:meshHeading | pubmed-meshheading:18633409... | lld:pubmed |
| pubmed-article:18633409 | pubmed:meshHeading | pubmed-meshheading:18633409... | lld:pubmed |
| pubmed-article:18633409 | pubmed:meshHeading | pubmed-meshheading:18633409... | lld:pubmed |
| pubmed-article:18633409 | pubmed:meshHeading | pubmed-meshheading:18633409... | lld:pubmed |
| pubmed-article:18633409 | pubmed:meshHeading | pubmed-meshheading:18633409... | lld:pubmed |
| pubmed-article:18633409 | pubmed:meshHeading | pubmed-meshheading:18633409... | lld:pubmed |
| pubmed-article:18633409 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18633409 | pubmed:articleTitle | Positive feedback of G1 cyclins ensures coherent cell cycle entry. | lld:pubmed |
