| pubmed-article:1863100 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1863100 | lifeskim:mentions | umls-concept:C0012634 | lld:lifeskim |
| pubmed-article:1863100 | lifeskim:mentions | umls-concept:C0002874 | lld:lifeskim |
| pubmed-article:1863100 | lifeskim:mentions | umls-concept:C0439661 | lld:lifeskim |
| pubmed-article:1863100 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:1863100 | pubmed:dateCreated | 1991-8-30 | lld:pubmed |
| pubmed-article:1863100 | pubmed:abstractText | Over 15 years, 42 children aged 2-14 years were diagnosed as having acquired aplastic anaemia. Adequate clinical details were available for 38 children who were categorised as very severe (n = 13), severe (n = 16), or nonsevere (n = 9) by the modified Camitta criteria. Treatment varied over the study period. Seven children received a bone marrow allograft from a full match family donor and three a matched unrelated donor transplant after failed treatment with antilymphocyte globulin. The remainder were treated with antilymphocyte globulin (n = 11), antilymphocyte globulin and oxymetholone (n = 4), oxymetholone with or without prednisolone (n = 12), or supportive treatment alone (n = 1). With a minimum follow up of one year since treatment, the five year survival was 70% for bone marrow transplantation with a family donor, 30% for antilymphocyte globulin, and 25% for oxymetholone. All three children with a matched unrelated donor transplant died. The prognosis of acquired aplastic anaemia remains poor for most children and new approaches to treatment are urgently required. | lld:pubmed |
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| pubmed-article:1863100 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1863100 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1863100 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:1863100 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1863100 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:1863100 | pubmed:issn | 1468-2044 | lld:pubmed |
| pubmed-article:1863100 | pubmed:author | pubmed-author:ChessellsJ... | lld:pubmed |
| pubmed-article:1863100 | pubmed:author | pubmed-author:HannI MIM | lld:pubmed |
| pubmed-article:1863100 | pubmed:author | pubmed-author:WebbD KDK | lld:pubmed |
| pubmed-article:1863100 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:1863100 | pubmed:volume | 66 | lld:pubmed |
| pubmed-article:1863100 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1863100 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1863100 | pubmed:pagination | 858-61 | lld:pubmed |
| pubmed-article:1863100 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:1863100 | pubmed:meshHeading | pubmed-meshheading:1863100-... | lld:pubmed |
| pubmed-article:1863100 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1863100 | pubmed:articleTitle | Acquired aplastic anaemia: still a serious disease. | lld:pubmed |
| pubmed-article:1863100 | pubmed:affiliation | Department of Haematology and Oncology, Hospital for Sick Children, London. | lld:pubmed |
| pubmed-article:1863100 | pubmed:publicationType | Journal Article | lld:pubmed |
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