| pubmed-article:18628249 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18628249 | lifeskim:mentions | umls-concept:C0007102 | lld:lifeskim |
| pubmed-article:18628249 | lifeskim:mentions | umls-concept:C0108082 | lld:lifeskim |
| pubmed-article:18628249 | lifeskim:mentions | umls-concept:C1563743 | lld:lifeskim |
| pubmed-article:18628249 | lifeskim:mentions | umls-concept:C0205419 | lld:lifeskim |
| pubmed-article:18628249 | lifeskim:mentions | umls-concept:C1335671 | lld:lifeskim |
| pubmed-article:18628249 | lifeskim:mentions | umls-concept:C0004083 | lld:lifeskim |
| pubmed-article:18628249 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:18628249 | pubmed:dateCreated | 2008-9-3 | lld:pubmed |
| pubmed-article:18628249 | pubmed:abstractText | Vitamin D receptor (VDR) gene variants have been variably associated with risk of colon cancer in epidemiologic studies. We sought to further clarify the relationship between colon cancer and three single-nucleotide polymorphisms (SNPs) in the VDR gene (Cdx-2, FokI and TaqI) in a population-based case-control study of 250 incident cases and 246 controls. Colon cancer cases were more frequently homozygous for the Cdx-2 A allele (9.2 versus 4.1%, P = 0.06). Cdx-2 AA homozygotes were at increased risk with an unadjusted odds ratio (OR) of 2.47 [95% confidence interval (CI): 1.13-5.37, P = 0.022]; adjustment for age, sex, body mass index (BMI), non-steroidal anti-inflammatory use and family history of colorectal cancer yielded an OR of 2.27 (CI: 0.95-5.41, P = 0.065). Carriers of the FokI TT genotype were also at increased risk with an adjusted OR of 1.87 (CI: 1.03-3.38, P = 0.038). Haplotype analyses showed significant increased colon cancer risk for carriers of the Cdx-2-FokI A-T haplotype and the FokI-TaqI T-G haplotype. The three-SNP Cdx-2-FokI-TaqI (A-T-G) haplotype showed a similar association with an adjusted OR of 3.63 (CI: 1.01-13.07). A strong positive association was observed for the Cdx-2 variant among individuals with low BMI or low waist circumference. Our results suggest that genetic variation at the VDR locus, in particular Cdx-2 and FokI SNPs, may influence colon cancer risk and these associations may be modified by adiposity. | lld:pubmed |
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| pubmed-article:18628249 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18628249 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18628249 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18628249 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:18628249 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18628249 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:18628249 | pubmed:issn | 1460-2180 | lld:pubmed |
| pubmed-article:18628249 | pubmed:author | pubmed-author:XXX | lld:pubmed |
| pubmed-article:18628249 | pubmed:author | pubmed-author:ElstonRobert... | lld:pubmed |
| pubmed-article:18628249 | pubmed:author | pubmed-author:TuckerThomas... | lld:pubmed |
| pubmed-article:18628249 | pubmed:author | pubmed-author:CaseyGrahamG | lld:pubmed |
| pubmed-article:18628249 | pubmed:author | pubmed-author:CicekMine SMS | lld:pubmed |
| pubmed-article:18628249 | pubmed:author | pubmed-author:Ochs-BalcomHe... | lld:pubmed |
| pubmed-article:18628249 | pubmed:author | pubmed-author:ThompsonChery... | lld:pubmed |
| pubmed-article:18628249 | pubmed:author | pubmed-author:J... | lld:pubmed |
| pubmed-article:18628249 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18628249 | pubmed:volume | 29 | lld:pubmed |
| pubmed-article:18628249 | pubmed:owner | NLM | lld:pubmed |
