| pubmed-article:18625843 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18625843 | lifeskim:mentions | umls-concept:C0205145 | lld:lifeskim |
| pubmed-article:18625843 | lifeskim:mentions | umls-concept:C1101610 | lld:lifeskim |
| pubmed-article:18625843 | lifeskim:mentions | umls-concept:C0333117 | lld:lifeskim |
| pubmed-article:18625843 | lifeskim:mentions | umls-concept:C0040649 | lld:lifeskim |
| pubmed-article:18625843 | lifeskim:mentions | umls-concept:C0033268 | lld:lifeskim |
| pubmed-article:18625843 | lifeskim:mentions | umls-concept:C0181586 | lld:lifeskim |
| pubmed-article:18625843 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:18625843 | lifeskim:mentions | umls-concept:C1519595 | lld:lifeskim |
| pubmed-article:18625843 | lifeskim:mentions | umls-concept:C1337054 | lld:lifeskim |
| pubmed-article:18625843 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:18625843 | pubmed:dateCreated | 2008-7-15 | lld:pubmed |
| pubmed-article:18625843 | pubmed:abstractText | MicroRNAs (miRNAs) are noncoding RNAs with important roles in regulating gene expression. In studying the earliest nuclear steps of miRNA biogenesis, we observe that primary miRNA (pri-miRNA) transcripts retained at transcription sites due to the deletion of 3'-end processing signals are converted more efficiently into precursor miRNAs (pre-miRNAs) than pri-miRNAs that are cleaved, polyadenylated, and released. Flanking exons, which also increase retention at transcription sites, likewise contribute to increased levels of intronic pri-miRNAs. Consistently, efficiently processed endogenous pri-miRNAs are enriched in chromatin-associated nuclear fractions. In contrast, pri-miRNAs that accumulate to high nuclear levels after cleavage and polyadenylation because of the presence of a viral RNA element (the ENE of the Kaposi's sarcoma-associated herpes virus polyadenylated nuclear RNA) are not efficiently processed to precursor or mature miRNAs. Exogenous pri-miRNAs unexpectedly localize to nuclear foci containing splicing factor SC35; yet these foci are unlikely to represent sites of miRNA transcription or processing. Together, our results suggest that pri-miRNA processing is enhanced by coupling to transcription. | lld:pubmed |
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| pubmed-article:18625843 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18625843 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18625843 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:18625843 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18625843 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:18625843 | pubmed:issn | 1540-8140 | lld:pubmed |
| pubmed-article:18625843 | pubmed:author | pubmed-author:SteitzJoan... | lld:pubmed |
| pubmed-article:18625843 | pubmed:author | pubmed-author:PawlickiJan... | lld:pubmed |
| pubmed-article:18625843 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18625843 | pubmed:day | 14 | lld:pubmed |
| pubmed-article:18625843 | pubmed:volume | 182 | lld:pubmed |
| pubmed-article:18625843 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18625843 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18625843 | pubmed:pagination | 61-76 | lld:pubmed |
| pubmed-article:18625843 | pubmed:dateRevised | 2011-9-27 | lld:pubmed |
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