Linked Life Data

18621524

Source:http://linkedlifedata.com/resource/pubmed/id/18621524

Statements in which the resource exists.
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pubmed-article:18621524pubmed:abstractTextModification of the potent imidazole-based B-Raf inhibitor SB-590885 resulted in the identification of a series of furan-based derivatives with enhanced CNS penetration. One such compound, SB-699393 (17), was examined in vivo to challenge the hypothesis that selective B-Raf inhibitors may be of value in the treatment of stroke.lld:pubmed
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pubmed-article:18621524pubmed:articleTitleThe identification of potent, selective and CNS penetrant furan-based inhibitors of B-Raf kinase.lld:pubmed
pubmed-article:18621524pubmed:affiliationDepartment of Medicinal Chemistry, Neurology and GI Centre of Excellence for Drug Discovery, GlaxoSmithKline Pharmaceuticals, New Frontiers Science Park, Third Avenue, Harlow, Essex CM19 5AW, UK. Andy.K.Takle@gsk.comlld:pubmed
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