| pubmed-article:18615578 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18615578 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:18615578 | lifeskim:mentions | umls-concept:C0027819 | lld:lifeskim |
| pubmed-article:18615578 | lifeskim:mentions | umls-concept:C0439861 | lld:lifeskim |
| pubmed-article:18615578 | lifeskim:mentions | umls-concept:C0017638 | lld:lifeskim |
| pubmed-article:18615578 | lifeskim:mentions | umls-concept:C0060926 | lld:lifeskim |
| pubmed-article:18615578 | lifeskim:mentions | umls-concept:C0657912 | lld:lifeskim |
| pubmed-article:18615578 | lifeskim:mentions | umls-concept:C1523116 | lld:lifeskim |
| pubmed-article:18615578 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:18615578 | pubmed:dateCreated | 2008-9-24 | lld:pubmed |
| pubmed-article:18615578 | pubmed:abstractText | Pregabalin and gabapentin are lipophilic amino acid derivatives of gamma-amino butyric acid that show anticonvulsant and analgesic activity against neuropathic pain. In this study, we investigated their actions on substance P-induced NF-kappaB activation in human neuroblastoma and rat glioma cells. Pregabalin and gabapentin decreased substance P-induced NF-kappaB activation in these cells. These drugs also inhibited NF-kappaB activation in rat spinal dorsal root ganglia cells pre-treated in vitro with substance P. These results suggest a previously undefined role of pregabalin and gabapentin in the regulation of inflammation-related intracellular signaling in both neuronal and glial cells. | lld:pubmed |
| pubmed-article:18615578 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18615578 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18615578 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:18615578 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18615578 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:18615578 | pubmed:issn | 1097-4644 | lld:pubmed |
| pubmed-article:18615578 | pubmed:author | pubmed-author:LeeJong HwaJH | lld:pubmed |
| pubmed-article:18615578 | pubmed:author | pubmed-author:ParkSeyeonS | lld:pubmed |
| pubmed-article:18615578 | pubmed:author | pubmed-author:HongYong-WooY... | lld:pubmed |
| pubmed-article:18615578 | pubmed:author | pubmed-author:HanDong WooDW | lld:pubmed |
| pubmed-article:18615578 | pubmed:author | pubmed-author:KimHyunkyungH | lld:pubmed |
| pubmed-article:18615578 | pubmed:author | pubmed-author:AhnEun SookES | lld:pubmed |
| pubmed-article:18615578 | pubmed:author | pubmed-author:MinKyung... | lld:pubmed |
| pubmed-article:18615578 | pubmed:copyrightInfo | (c) 2008 Wiley-Liss, Inc. | lld:pubmed |
| pubmed-article:18615578 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18615578 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:18615578 | pubmed:volume | 105 | lld:pubmed |
| pubmed-article:18615578 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18615578 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18615578 | pubmed:pagination | 414-23 | lld:pubmed |
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| pubmed-article:18615578 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18615578 | pubmed:articleTitle | Pregabalin and gabapentin inhibit substance P-induced NF-kappaB activation in neuroblastoma and glioma cells. | lld:pubmed |
| pubmed-article:18615578 | pubmed:affiliation | Dongduk Women's University, Department of Applied Chemistry, Seoul, Korea. sypark21@dongduk.ac.kr | lld:pubmed |
| pubmed-article:18615578 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18615578 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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