| pubmed-article:18614045 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18614045 | lifeskim:mentions | umls-concept:C0598312 | lld:lifeskim |
| pubmed-article:18614045 | lifeskim:mentions | umls-concept:C0439855 | lld:lifeskim |
| pubmed-article:18614045 | lifeskim:mentions | umls-concept:C0079411 | lld:lifeskim |
| pubmed-article:18614045 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:18614045 | pubmed:dateCreated | 2008-7-10 | lld:pubmed |
| pubmed-article:18614045 | pubmed:abstractText | The histone H2A variant H2AX is rapidly phosphorylated in response to DNA double-stranded breaks to produce gamma-H2AX. gamma-H2AX stabilizes cell-cycle checkpoint proteins and DNA repair factors at the break site. We previously found that the protein phosphatase PP2A is required to resolve gamma-H2AX foci and complete DNA repair after exogenous DNA damage. Here we describe a three-protein PP4 phosphatase complex in mammalian cells, containing PP4C, PP4R2, and PP4R3beta, that specifically dephosphorylates ATR-mediated gamma-H2AX generated during DNA replication. PP4 efficiently dephosphorylates gamma-H2AX within mononucleosomes in vitro and does not directly alter ATR or checkpoint kinase activity, suggesting that PP4 acts directly on gamma-H2AX in cells. When the PP4 complex is silenced, repair of DNA replication-mediated breaks is inefficient, and cells are hypersensitive to DNA replication inhibitors, but not radiomimetic drugs. Therefore, gamma-H2AX elimination at DNA damage foci is required for DNA damage repair, but accomplishing this task involves distinct phosphatases with potentially overlapping roles. | lld:pubmed |
| pubmed-article:18614045 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18614045 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18614045 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18614045 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18614045 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18614045 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18614045 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18614045 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18614045 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18614045 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18614045 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18614045 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18614045 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18614045 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18614045 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18614045 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18614045 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18614045 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18614045 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:18614045 | pubmed:issn | 1097-4164 | lld:pubmed |
| pubmed-article:18614045 | pubmed:author | pubmed-author:PfeiferGerd... | lld:pubmed |
| pubmed-article:18614045 | pubmed:author | pubmed-author:LiebermanJudy... | lld:pubmed |
| pubmed-article:18614045 | pubmed:author | pubmed-author:WeinstockDavi... | lld:pubmed |
| pubmed-article:18614045 | pubmed:author | pubmed-author:XuXingzhiX | lld:pubmed |
| pubmed-article:18614045 | pubmed:author | pubmed-author:DykxhoornDere... | lld:pubmed |
| pubmed-article:18614045 | pubmed:author | pubmed-author:ChowdhuryDipa... | lld:pubmed |
| pubmed-article:18614045 | pubmed:author | pubmed-author:LiaoJiJ | lld:pubmed |
| pubmed-article:18614045 | pubmed:author | pubmed-author:AhmedFariyalF | lld:pubmed |
| pubmed-article:18614045 | pubmed:author | pubmed-author:ZhongXueyanX | lld:pubmed |
| pubmed-article:18614045 | pubmed:author | pubmed-author:ZhongJianingJ | lld:pubmed |
| pubmed-article:18614045 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18614045 | pubmed:day | 11 | lld:pubmed |
| pubmed-article:18614045 | pubmed:volume | 31 | lld:pubmed |
| pubmed-article:18614045 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18614045 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18614045 | pubmed:pagination | 33-46 | lld:pubmed |
| pubmed-article:18614045 | pubmed:dateRevised | 2011-4-27 | lld:pubmed |
| pubmed-article:18614045 | pubmed:meshHeading | pubmed-meshheading:18614045... | lld:pubmed |
| pubmed-article:18614045 | pubmed:meshHeading | pubmed-meshheading:18614045... | lld:pubmed |
| pubmed-article:18614045 | pubmed:meshHeading | pubmed-meshheading:18614045... | lld:pubmed |
| pubmed-article:18614045 | pubmed:meshHeading | pubmed-meshheading:18614045... | lld:pubmed |
| pubmed-article:18614045 | pubmed:meshHeading | pubmed-meshheading:18614045... | lld:pubmed |
| pubmed-article:18614045 | pubmed:meshHeading | pubmed-meshheading:18614045... | lld:pubmed |
| pubmed-article:18614045 | pubmed:meshHeading | pubmed-meshheading:18614045... | lld:pubmed |
| pubmed-article:18614045 | pubmed:meshHeading | pubmed-meshheading:18614045... | lld:pubmed |
| pubmed-article:18614045 | pubmed:meshHeading | pubmed-meshheading:18614045... | lld:pubmed |
| pubmed-article:18614045 | pubmed:meshHeading | pubmed-meshheading:18614045... | lld:pubmed |
| pubmed-article:18614045 | pubmed:meshHeading | pubmed-meshheading:18614045... | lld:pubmed |
| pubmed-article:18614045 | pubmed:meshHeading | pubmed-meshheading:18614045... | lld:pubmed |
| pubmed-article:18614045 | pubmed:meshHeading | pubmed-meshheading:18614045... | lld:pubmed |
| pubmed-article:18614045 | pubmed:meshHeading | pubmed-meshheading:18614045... | lld:pubmed |
| pubmed-article:18614045 | pubmed:meshHeading | pubmed-meshheading:18614045... | lld:pubmed |
| pubmed-article:18614045 | pubmed:meshHeading | pubmed-meshheading:18614045... | lld:pubmed |
| pubmed-article:18614045 | pubmed:meshHeading | pubmed-meshheading:18614045... | lld:pubmed |
| pubmed-article:18614045 | pubmed:meshHeading | pubmed-meshheading:18614045... | lld:pubmed |
| pubmed-article:18614045 | pubmed:meshHeading | pubmed-meshheading:18614045... | lld:pubmed |
| pubmed-article:18614045 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18614045 | pubmed:articleTitle | A PP4-phosphatase complex dephosphorylates gamma-H2AX generated during DNA replication. | lld:pubmed |
| pubmed-article:18614045 | pubmed:affiliation | Immune Disease Institute, Harvard Medical School, Boston, MA 02115, USA. dipanjan_chowdhury@dfci.harvard.edu | lld:pubmed |
| pubmed-article:18614045 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18614045 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:18614045 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| http://bio2rdf.org/pubmed:1... | skos:relatedMatch | pubmed-article:18614045 | lld:mappings |
| entrez-gene:3014 | entrezgene:pubmed | pubmed-article:18614045 | lld:entrezgene |
| entrez-gene:5531 | entrezgene:pubmed | pubmed-article:18614045 | lld:entrezgene |
| entrez-gene:57223 | entrezgene:pubmed | pubmed-article:18614045 | lld:entrezgene |
| entrez-gene:151987 | entrezgene:pubmed | pubmed-article:18614045 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:18614045 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:18614045 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:18614045 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:18614045 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:18614045 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:18614045 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:18614045 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:18614045 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:18614045 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:18614045 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:18614045 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:18614045 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:18614045 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:18614045 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:18614045 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:18614045 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:18614045 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:18614045 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:18614045 | lld:pubmed |
