| pubmed-article:1861073 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1861073 | lifeskim:mentions | umls-concept:C0001511 | lld:lifeskim |
| pubmed-article:1861073 | lifeskim:mentions | umls-concept:C0206431 | lld:lifeskim |
| pubmed-article:1861073 | lifeskim:mentions | umls-concept:C1709059 | lld:lifeskim |
| pubmed-article:1861073 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:1861073 | pubmed:dateCreated | 1991-8-30 | lld:pubmed |
| pubmed-article:1861073 | pubmed:abstractText | Incubation of peritoneal macrophages in vitro before fixation increased their ability to present exogenous peptides to 3A9 T hybridoma cells. The enhanced level of presentation correlated with a greatly increased, peptide-specific adhesion of 3A9 cells to the macrophages, whereas peptide-independent adhesion was minimal and essentially unaltered. 3A9 cells exhibited rapid peptide-specific adhesion (plateau by 5 to 10 min) and deadhesion (complete reversal by 5 min). Peptide-specific adhesion was blocked by anti-I-Ak and anti-LFA-1. Interaction of T cell receptors and CD-4 with peptide-I-Ak complexes appeared to provide little direct contribution to the avidity of T cell-macrophage adhesion, but activated a LFA-1-mediated adhesion mechanism. In addition, anti-T cell receptor, anti-CD3, and anti-CD4 antibodies themselves activated LFA-1-dependent adhesion in the absence of peptide. Unlike the peptide-induced adhesion, this adhesion was similar for macrophages whether or not they were incubated in vitro before fixation. We conclude that the different macrophage populations supported LFA-1-mediated adhesion equally. Therefore, the enhancement of T cell stimulation observed after in vitro incubation of macrophages was due to increased peptide presentation and consequently increased triggering of LFA-1-mediated adhesion. Mechanisms may exist to regulate the effectiveness with which peptide-class II MHC complexes are displayed for T cell recognition. | lld:pubmed |
| pubmed-article:1861073 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1861073 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1861073 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:1861073 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1861073 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1861073 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1861073 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1861073 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1861073 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1861073 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1861073 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:1861073 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:1861073 | pubmed:author | pubmed-author:UnanueE RER | lld:pubmed |
| pubmed-article:1861073 | pubmed:author | pubmed-author:HardingC VCV | lld:pubmed |
| pubmed-article:1861073 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1861073 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:1861073 | pubmed:volume | 147 | lld:pubmed |
| pubmed-article:1861073 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1861073 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1861073 | pubmed:pagination | 767-73 | lld:pubmed |
| pubmed-article:1861073 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:1861073 | pubmed:meshHeading | pubmed-meshheading:1861073-... | lld:pubmed |
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| pubmed-article:1861073 | pubmed:meshHeading | pubmed-meshheading:1861073-... | lld:pubmed |
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| pubmed-article:1861073 | pubmed:meshHeading | pubmed-meshheading:1861073-... | lld:pubmed |
| pubmed-article:1861073 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1861073 | pubmed:articleTitle | Modulation of antigen presentation and peptide-MHC-specific, LFA-1-dependent T cell-macrophage adhesion. | lld:pubmed |
| pubmed-article:1861073 | pubmed:affiliation | Department of Pathology, Washington University School of Medicine, St. Louis, MO 63110. | lld:pubmed |
| pubmed-article:1861073 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1861073 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:1861073 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:1861073 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1861073 | lld:pubmed |
