| pubmed-article:18606695 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18606695 | lifeskim:mentions | umls-concept:C0032285 | lld:lifeskim |
| pubmed-article:18606695 | lifeskim:mentions | umls-concept:C0597258 | lld:lifeskim |
| pubmed-article:18606695 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:18606695 | lifeskim:mentions | umls-concept:C0682552 | lld:lifeskim |
| pubmed-article:18606695 | lifeskim:mentions | umls-concept:C1145670 | lld:lifeskim |
| pubmed-article:18606695 | lifeskim:mentions | umls-concept:C0077503 | lld:lifeskim |
| pubmed-article:18606695 | lifeskim:mentions | umls-concept:C0271510 | lld:lifeskim |
| pubmed-article:18606695 | lifeskim:mentions | umls-concept:C0333348 | lld:lifeskim |
| pubmed-article:18606695 | lifeskim:mentions | umls-concept:C1880177 | lld:lifeskim |
| pubmed-article:18606695 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:18606695 | pubmed:dateCreated | 2008-7-8 | lld:pubmed |
| pubmed-article:18606695 | pubmed:abstractText | The opportunistic organism Pneumocystis carinii (Pc) produces a life-threatening pneumonia (PcP) in patients with low CD4(+) T cell counts. Animal models of HIV-AIDS-related PcP indicate that development of severe disease is dependent on the presence of CD8(+) T cells and the TNF receptors (TNFR) TNFRsf1a and TNFRsf1b. To distinguish roles of parenchymal and hematopoietic cell TNF signaling in PcP-related lung injury, murine bone marrow transplant chimeras of wild-type, C57BL6/J, and TNFRsf1a/1b double-null origin were generated, CD4(+) T cell depleted, and inoculated with Pc. As expected, C57 --> C57 chimeras (donor marrow --> recipient) developed significant disease as assessed by weight loss, impaired pulmonary function (lung resistance and dynamic lung compliance), and inflammatory cell infiltration. In contrast, TNFRsf1a/1b(-/-) --> TNFRsf1a/1b(-/-) mice were relatively mildly affected despite carrying the greatest organism burden. Mice solely lacking parenchymal TNFRs (C57 --> TNFRsf1a/1b(-/-)) had milder disease than did C57 --> C57 mice. Both groups of mice with TNFR-deficient parenchymal cells had low bronchoalveolar lavage fluid total cell counts and fewer lavageable CD8(+) T cells than did C57 --> C57 mice, suggesting that parenchymal TNFR signaling contributes to PcP-related immunopathology through the recruitment of damaging immune cells. Interestingly, mice with wild-type parenchymal cells but TNFRsf1a/1b(-/-) hematopoietic cells (TNFRsf1a/1b(-/-) --> C57) displayed exacerbated disease characterized by increased MCP-1 and KC production in the lung and increased macrophage and lymphocyte numbers in the lavage, indicating a dysregulated immune response. This study supports a key role of parenchymal cell TNFRs in lung injury induced by Pc and a potential protective effect of receptors on radiosensitive, bone marrow-derived cells. | lld:pubmed |
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| pubmed-article:18606695 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18606695 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18606695 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:18606695 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18606695 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:18606695 | pubmed:issn | 1550-6606 | lld:pubmed |
| pubmed-article:18606695 | pubmed:author | pubmed-author:GigliottiFran... | lld:pubmed |
| pubmed-article:18606695 | pubmed:author | pubmed-author:FinkelsteinJa... | lld:pubmed |
| pubmed-article:18606695 | pubmed:author | pubmed-author:WrightTerry... | lld:pubmed |
| pubmed-article:18606695 | pubmed:author | pubmed-author:PryhuberGlori... | lld:pubmed |
| pubmed-article:18606695 | pubmed:author | pubmed-author:O'ReillyMicha... | lld:pubmed |
| pubmed-article:18606695 | pubmed:author | pubmed-author:HuyckHeidie... | lld:pubmed |
| pubmed-article:18606695 | pubmed:author | pubmed-author:BhagwatSamirS | lld:pubmed |
| pubmed-article:18606695 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18606695 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:18606695 | pubmed:volume | 181 | lld:pubmed |
| pubmed-article:18606695 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18606695 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18606695 | pubmed:pagination | 1409-19 | lld:pubmed |
| pubmed-article:18606695 | pubmed:dateRevised | 2011-4-21 | lld:pubmed |
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| pubmed-article:18606695 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18606695 | pubmed:articleTitle | Parenchymal cell TNF receptors contribute to inflammatory cell recruitment and respiratory failure in Pneumocystis carinii-induced pneumonia. | lld:pubmed |
| pubmed-article:18606695 | pubmed:affiliation | Department of Pediatrics, University of Rochester Medical Center, Rochester, NY 14642, USA. gloria_pryhuber@urmc.rochester.edu | lld:pubmed |
| pubmed-article:18606695 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18606695 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:18606695 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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