| pubmed-article:18606402 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18606402 | lifeskim:mentions | umls-concept:C0032659 | lld:lifeskim |
| pubmed-article:18606402 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:18606402 | lifeskim:mentions | umls-concept:C1704628 | lld:lifeskim |
| pubmed-article:18606402 | lifeskim:mentions | umls-concept:C0230744 | lld:lifeskim |
| pubmed-article:18606402 | lifeskim:mentions | umls-concept:C0379900 | lld:lifeskim |
| pubmed-article:18606402 | lifeskim:mentions | umls-concept:C0005903 | lld:lifeskim |
| pubmed-article:18606402 | lifeskim:mentions | umls-concept:C1420214 | lld:lifeskim |
| pubmed-article:18606402 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:18606402 | lifeskim:mentions | umls-concept:C0127400 | lld:lifeskim |
| pubmed-article:18606402 | pubmed:issue | 1-3 | lld:pubmed |
| pubmed-article:18606402 | pubmed:dateCreated | 2008-8-4 | lld:pubmed |
| pubmed-article:18606402 | pubmed:abstractText | Disturbances in the serotonergic system are implicated in many central nervous system disorders. The serotonin transporter (SERT) regulates the serotonin homeostasis in the synapse. We recently developed a rat which lacks the serotonin transporter (SERT(-/-)). It is likely that adaptive changes take place at the level of pre- and postsynaptic 5-HT receptors. Because autonomic responses are often used to measure 5-HT(1A) receptor function, we analysed these responses by examining the effects of a 5-HT(1A) receptor agonist and antagonist under in vivo conditions in the SERT(-/-) rat. Moreover, we studied the effect of a mild stressor on the body temperature (stress-induced hyperthermia) because of the known involvement of 5-HT(1A) receptors in this phenomenon. Results show that core body temperature did not differ between genotypes under basal, non-stressed conditions. Compared to SERT(+/+) rats, stress-induced hyperthermia was reduced in SERT(-/-) rats. The 5-HT(1A) receptor agonist [R(+)-N-(2[4-(2,3-dihydro-2-2-hydroxy-methyl-1,4-benzodioxin-5-yl)-1-piperazininyl]ethyl)-4-fluorobenzoamide HCl (flesinoxan) reduced stress-induced hyperthermia in both genotypes. The flesinoxan-induced hypothermia in SERT(+/+) rats was blocked by the 5-HT(1A) receptor antagonist [N-(2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl)-N-(2-pyridinyl) cyclohexane carboxamide 3HCl (WAY100635). Moreover, WAY100635-induced hyperthermia in SERT(-/-), but not in SERT(+/+) rats. In SERT(-/-) rats, WAY100635 completely blocked the flesinoxan-induced reduction of stress-induced hyperthermia. Interestingly, flesinoxan-induced hypothermia was absent in SERT(-/-) rats. It is concluded that the SERT knockout rat reveals that 5-HT(1A) receptors modulating stress-induced hyperthermia belong to a population of receptors that differs from that involved in hypothermia. | lld:pubmed |
| pubmed-article:18606402 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18606402 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18606402 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18606402 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18606402 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:18606402 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18606402 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18606402 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18606402 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18606402 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:18606402 | pubmed:issn | 0014-2999 | lld:pubmed |
| pubmed-article:18606402 | pubmed:author | pubmed-author:OlivierBerend... | lld:pubmed |
| pubmed-article:18606402 | pubmed:author | pubmed-author:EllenbroekBar... | lld:pubmed |
| pubmed-article:18606402 | pubmed:author | pubmed-author:CoolsAlexande... | lld:pubmed |
| pubmed-article:18606402 | pubmed:author | pubmed-author:HombergJudith... | lld:pubmed |
| pubmed-article:18606402 | pubmed:author | pubmed-author:OlivierJoceli... | lld:pubmed |
| pubmed-article:18606402 | pubmed:author | pubmed-author:CuppenEdwinE | lld:pubmed |
| pubmed-article:18606402 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18606402 | pubmed:day | 20 | lld:pubmed |
| pubmed-article:18606402 | pubmed:volume | 590 | lld:pubmed |
| pubmed-article:18606402 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18606402 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18606402 | pubmed:pagination | 190-7 | lld:pubmed |
| pubmed-article:18606402 | pubmed:meshHeading | pubmed-meshheading:18606402... | lld:pubmed |
| pubmed-article:18606402 | pubmed:meshHeading | pubmed-meshheading:18606402... | lld:pubmed |
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| pubmed-article:18606402 | pubmed:meshHeading | pubmed-meshheading:18606402... | lld:pubmed |
| pubmed-article:18606402 | pubmed:meshHeading | pubmed-meshheading:18606402... | lld:pubmed |
| pubmed-article:18606402 | pubmed:meshHeading | pubmed-meshheading:18606402... | lld:pubmed |
| pubmed-article:18606402 | pubmed:meshHeading | pubmed-meshheading:18606402... | lld:pubmed |
| pubmed-article:18606402 | pubmed:meshHeading | pubmed-meshheading:18606402... | lld:pubmed |
| pubmed-article:18606402 | pubmed:meshHeading | pubmed-meshheading:18606402... | lld:pubmed |
| pubmed-article:18606402 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18606402 | pubmed:articleTitle | Stress-induced hyperthermia and basal body temperature are mediated by different 5-HT(1A) receptor populations: a study in SERT knockout rats. | lld:pubmed |
| pubmed-article:18606402 | pubmed:affiliation | Department Cognitive Neuroscience: Psychoneuropharmacology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands. j.olivier@cns.umcn.nl | lld:pubmed |
| pubmed-article:18606402 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18606402 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:24473 | entrezgene:pubmed | pubmed-article:18606402 | lld:entrezgene |
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