| pubmed-article:18605754 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18605754 | lifeskim:mentions | umls-concept:C0013227 | lld:lifeskim |
| pubmed-article:18605754 | lifeskim:mentions | umls-concept:C0205101 | lld:lifeskim |
| pubmed-article:18605754 | lifeskim:mentions | umls-concept:C0205102 | lld:lifeskim |
| pubmed-article:18605754 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:18605754 | lifeskim:mentions | umls-concept:C0037628 | lld:lifeskim |
| pubmed-article:18605754 | lifeskim:mentions | umls-concept:C1563732 | lld:lifeskim |
| pubmed-article:18605754 | lifeskim:mentions | umls-concept:C1706211 | lld:lifeskim |
| pubmed-article:18605754 | lifeskim:mentions | umls-concept:C1880177 | lld:lifeskim |
| pubmed-article:18605754 | lifeskim:mentions | umls-concept:C2348438 | lld:lifeskim |
| pubmed-article:18605754 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:18605754 | lifeskim:mentions | umls-concept:C1627358 | lld:lifeskim |
| pubmed-article:18605754 | pubmed:issue | 30 | lld:pubmed |
| pubmed-article:18605754 | pubmed:dateCreated | 2008-7-28 | lld:pubmed |
| pubmed-article:18605754 | pubmed:abstractText | Relationships of electrostatic interaction and encapsulation between poly(amidoamine) (PAMAM) dendrimers and negatively charged drug molecules have been investigated by aqueous solubility and NMR ( (1)H NMR and two-dimensional nuclear Overhauser effect spectroscopy (2D-NOESY)) studies. PAMAM dendrimers significantly increased the solubilities of phenobarbital and sulfamethoxazole, but scarcely influenced those of primidone and trimethoprim. Moreover, (1)H NMR and 2D-NOESY measurements indicated that few phenobarbital or sulfamethoxazole molecules were entrapped in the cavities of low-generation dendrimers (generation 3, G3). These results suggest that external electrostatic interaction contributes more to the solubility enhancement of drugs than internal encapsulation. | lld:pubmed |
| pubmed-article:18605754 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18605754 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18605754 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18605754 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18605754 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18605754 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18605754 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18605754 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18605754 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:18605754 | pubmed:issn | 1520-6106 | lld:pubmed |
| pubmed-article:18605754 | pubmed:author | pubmed-author:LiYiwenY | lld:pubmed |
| pubmed-article:18605754 | pubmed:author | pubmed-author:XuTongwenT | lld:pubmed |
| pubmed-article:18605754 | pubmed:author | pubmed-author:YiyunChengC | lld:pubmed |
| pubmed-article:18605754 | pubmed:author | pubmed-author:WuQinglinQ | lld:pubmed |
| pubmed-article:18605754 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18605754 | pubmed:day | 31 | lld:pubmed |
| pubmed-article:18605754 | pubmed:volume | 112 | lld:pubmed |
| pubmed-article:18605754 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18605754 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18605754 | pubmed:pagination | 8884-90 | lld:pubmed |
| pubmed-article:18605754 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
| pubmed-article:18605754 | pubmed:meshHeading | pubmed-meshheading:18605754... | lld:pubmed |
| pubmed-article:18605754 | pubmed:meshHeading | pubmed-meshheading:18605754... | lld:pubmed |
| pubmed-article:18605754 | pubmed:meshHeading | pubmed-meshheading:18605754... | lld:pubmed |
| pubmed-article:18605754 | pubmed:meshHeading | pubmed-meshheading:18605754... | lld:pubmed |
| pubmed-article:18605754 | pubmed:meshHeading | pubmed-meshheading:18605754... | lld:pubmed |
| pubmed-article:18605754 | pubmed:meshHeading | pubmed-meshheading:18605754... | lld:pubmed |
| pubmed-article:18605754 | pubmed:meshHeading | pubmed-meshheading:18605754... | lld:pubmed |
| pubmed-article:18605754 | pubmed:meshHeading | pubmed-meshheading:18605754... | lld:pubmed |
| pubmed-article:18605754 | pubmed:meshHeading | pubmed-meshheading:18605754... | lld:pubmed |
| pubmed-article:18605754 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18605754 | pubmed:articleTitle | External electrostatic interaction versus internal encapsulation between cationic dendrimers and negatively charged drugs: which contributes more to solubility enhancement of the drugs? | lld:pubmed |
| pubmed-article:18605754 | pubmed:affiliation | Laboratory of Functional Membranes, Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, China. yycheng@mail.ustc.edu.cn | lld:pubmed |
| pubmed-article:18605754 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18605754 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:18605754 | lld:pubmed |
