pubmed-article:18603373 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:18603373 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
pubmed-article:18603373 | lifeskim:mentions | umls-concept:C0018787 | lld:lifeskim |
pubmed-article:18603373 | lifeskim:mentions | umls-concept:C0442805 | lld:lifeskim |
pubmed-article:18603373 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
pubmed-article:18603373 | lifeskim:mentions | umls-concept:C1335671 | lld:lifeskim |
pubmed-article:18603373 | pubmed:issue | 2 | lld:pubmed |
pubmed-article:18603373 | pubmed:dateCreated | 2008-7-15 | lld:pubmed |
pubmed-article:18603373 | pubmed:abstractText | Changes of cardiac M2-muscarinic receptor (M2-mAChR) gene expression was investigated in type-1 like diabetic rats induced by intravenous injection of streptozotocin (STZ) and type-2 like diabetic rats induced by fed with fructose-rich chow. Systolic blood pressure (SBP) in STZ-diabetic rats was significantly lower than that in age-matched non-diabetic rats, while the SBP in type-2 like diabetic rats was higher than in non-diabetic rats. Also, the mRNA or protein level of cardiac M2-mAChR in STZ-diabetic rats was markedly higher than non-diabetic rats, but it was not observed in type-2 like diabetic rats as compared to age-matched non-diabetic rats. Arecaidine propargyl ester (APE), the agonist of M2-mAChR, produced a marked reduction of heart rate in STZ-diabetic rats but made less influence on heart rate in fructose-fed rats or non-diabetic rats. The results suggest that cardiac M2-mAChR gene expression is raised in type-1 like diabetic rats but not in type-2 like diabetic rats, this difference mainly due to hyperglycemia, for the production of hypotension in diabetic disorders. | lld:pubmed |
pubmed-article:18603373 | pubmed:language | eng | lld:pubmed |
pubmed-article:18603373 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:18603373 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:18603373 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:18603373 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:18603373 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:18603373 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:18603373 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:18603373 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:18603373 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:18603373 | pubmed:month | Aug | lld:pubmed |
pubmed-article:18603373 | pubmed:issn | 0304-3940 | lld:pubmed |
pubmed-article:18603373 | pubmed:author | pubmed-author:LiuI-MinIM | lld:pubmed |
pubmed-article:18603373 | pubmed:author | pubmed-author:ChengJuei-Tan... | lld:pubmed |
pubmed-article:18603373 | pubmed:author | pubmed-author:LeeLiang-Ming... | lld:pubmed |
pubmed-article:18603373 | pubmed:author | pubmed-author:ChangCheng... | lld:pubmed |
pubmed-article:18603373 | pubmed:author | pubmed-author:ChengKai-Chun... | lld:pubmed |
pubmed-article:18603373 | pubmed:author | pubmed-author:KouDai-HuangD... | lld:pubmed |
pubmed-article:18603373 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:18603373 | pubmed:day | 22 | lld:pubmed |
pubmed-article:18603373 | pubmed:volume | 441 | lld:pubmed |
pubmed-article:18603373 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:18603373 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:18603373 | pubmed:pagination | 201-4 | lld:pubmed |
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pubmed-article:18603373 | pubmed:year | 2008 | lld:pubmed |
pubmed-article:18603373 | pubmed:articleTitle | Increase of cardiac M2-muscarinic receptor gene expression in type-1 but not in type-2 diabetic rats. | lld:pubmed |
pubmed-article:18603373 | pubmed:affiliation | Department of Urology, College of Medicine and Wan Fang Hospital, Taipei Medical University, Taipei City, Taiwan, ROC. | lld:pubmed |
pubmed-article:18603373 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:18603373 | pubmed:publicationType | Comparative Study | lld:pubmed |
pubmed-article:18603373 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:18603373 | lld:pubmed |