| pubmed-article:18599325 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18599325 | lifeskim:mentions | umls-concept:C0018894 | lld:lifeskim |
| pubmed-article:18599325 | lifeskim:mentions | umls-concept:C0439682 | lld:lifeskim |
| pubmed-article:18599325 | lifeskim:mentions | umls-concept:C0282637 | lld:lifeskim |
| pubmed-article:18599325 | lifeskim:mentions | umls-concept:C0962190 | lld:lifeskim |
| pubmed-article:18599325 | lifeskim:mentions | umls-concept:C0079411 | lld:lifeskim |
| pubmed-article:18599325 | lifeskim:mentions | umls-concept:C0127400 | lld:lifeskim |
| pubmed-article:18599325 | lifeskim:mentions | umls-concept:C0332291 | lld:lifeskim |
| pubmed-article:18599325 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:18599325 | pubmed:dateCreated | 2008-7-17 | lld:pubmed |
| pubmed-article:18599325 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18599325 | pubmed:abstractText | After activation, CD4(+) helper T (Th) cells differentiate into distinct effector subsets. Although chemokine (C-X-C motif) receptor 5-expressing T follicular helper (Tfh) cells are important in humoral immunity, their developmental regulation is unclear. Here we show that Tfh cells had a distinct gene expression profile and developed in vivo independently of the Th1 or Th2 cell lineages. Tfh cell generation was regulated by ICOS ligand (ICOSL) expressed on B cells and was dependent on interleukin-21 (IL-21), IL-6, and signal transducer and activator of transcription 3 (STAT3). However, unlike Th17 cells, differentiation of Tfh cells did not require transforming growth factor beta (TGF-beta) or Th17-specific orphan nuclear receptors RORalpha and RORgamma in vivo. Finally, naive T cells activated in vitro in the presence of IL-21 but not TGF-beta signaling preferentially acquired Tfh gene expression and promoted germinal-center reactions in vivo. This study thus demonstrates that Tfh is a distinct Th cell lineage. | lld:pubmed |
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| pubmed-article:18599325 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18599325 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18599325 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18599325 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18599325 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18599325 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18599325 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18599325 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18599325 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18599325 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:18599325 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18599325 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18599325 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:18599325 | pubmed:issn | 1097-4180 | lld:pubmed |
| pubmed-article:18599325 | pubmed:author | pubmed-author:JettenAnton... | lld:pubmed |
| pubmed-article:18599325 | pubmed:author | pubmed-author:TianQiangQ | lld:pubmed |
| pubmed-article:18599325 | pubmed:author | pubmed-author:MaLiL | lld:pubmed |
| pubmed-article:18599325 | pubmed:author | pubmed-author:WatowichSteph... | lld:pubmed |
| pubmed-article:18599325 | pubmed:author | pubmed-author:DongChenC | lld:pubmed |
| pubmed-article:18599325 | pubmed:author | pubmed-author:YangXuexian... | lld:pubmed |
| pubmed-article:18599325 | pubmed:author | pubmed-author:KangHong... | lld:pubmed |
| pubmed-article:18599325 | pubmed:author | pubmed-author:HwangDaeheeD | lld:pubmed |
| pubmed-article:18599325 | pubmed:author | pubmed-author:ChungYeonseok... | lld:pubmed |
| pubmed-article:18599325 | pubmed:author | pubmed-author:NurievaRoza... | lld:pubmed |
| pubmed-article:18599325 | pubmed:author | pubmed-author:WangYi-hongYH | lld:pubmed |
| pubmed-article:18599325 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18599325 | pubmed:day | 18 | lld:pubmed |
| pubmed-article:18599325 | pubmed:volume | 29 | lld:pubmed |
| pubmed-article:18599325 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18599325 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18599325 | pubmed:pagination | 138-49 | lld:pubmed |
