| pubmed-article:1859884 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1859884 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:1859884 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:1859884 | lifeskim:mentions | umls-concept:C0123771 | lld:lifeskim |
| pubmed-article:1859884 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:1859884 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:1859884 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:1859884 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:1859884 | pubmed:dateCreated | 1991-9-4 | lld:pubmed |
| pubmed-article:1859884 | pubmed:abstractText | Interleukin-4 (IL-4) regulates multiple stages of the antigen-dependent phase of B-cell development. However, its precise role in regulating B lymphopoiesis in bone marrow is not as well defined. We examined whether surface IgM- normal and leukemic human B-cell precursors (BCP) expressed IL-4 receptors using biotinylated IL-4. Constitutive expression of IL-4 receptors was detected on both normal and leukemic BCP. A higher percentage of normal BCP (82% +/- 15%) expressed IL-4 receptors compared with leukemic BCP (44% +/- 8%). Using mean fluorescent intensity as an indicator of receptor level on the IL-4 receptor positive cells, normal (91 +/- 41) and leukemic (44 +/- 37) BCP expressed comparable numbers of receptors. IL-4 induced the expression of CD23 on 30% of the leukemic BCP cases examined. IL-4 induced CD23 on surface IgM+ fetal bone marrow lymphoid cells but not on the surface IgM- normal BCP, despite the presence of detectable receptors on the surface IgM- cells. IL-4 did not stimulate proliferation of normal BCP, nor could it enhance the effect of recombinant IL-7 or low molecular weight B-cell growth factor. However, IL-4 increased the expression of surface IgM and surface Ig kappa on in vitro differentiated pre-B cells. Our collective results identify no role for IL-4 in the proliferation of normal or leukemic BCP, but identify a role in the enhancement of surface Ig expression during pre-B to B-cell differentiation. | lld:pubmed |
| pubmed-article:1859884 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1859884 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1859884 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1859884 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1859884 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1859884 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:1859884 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1859884 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1859884 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1859884 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1859884 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:1859884 | pubmed:issn | 0006-4971 | lld:pubmed |
| pubmed-article:1859884 | pubmed:author | pubmed-author:LeBienT WTW | lld:pubmed |
| pubmed-article:1859884 | pubmed:author | pubmed-author:ArmitageR JRJ | lld:pubmed |
| pubmed-article:1859884 | pubmed:author | pubmed-author:LawC LCL | lld:pubmed |
| pubmed-article:1859884 | pubmed:author | pubmed-author:VillablancaJ... | lld:pubmed |
| pubmed-article:1859884 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1859884 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:1859884 | pubmed:volume | 78 | lld:pubmed |
| pubmed-article:1859884 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1859884 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1859884 | pubmed:pagination | 703-10 | lld:pubmed |
| pubmed-article:1859884 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:1859884 | pubmed:meshHeading | pubmed-meshheading:1859884-... | lld:pubmed |
| pubmed-article:1859884 | pubmed:meshHeading | pubmed-meshheading:1859884-... | lld:pubmed |
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| pubmed-article:1859884 | pubmed:meshHeading | pubmed-meshheading:1859884-... | lld:pubmed |
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| pubmed-article:1859884 | pubmed:meshHeading | pubmed-meshheading:1859884-... | lld:pubmed |
| pubmed-article:1859884 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1859884 | pubmed:articleTitle | Expression of interleukin-4 receptors on early human B-lineage cells. | lld:pubmed |
| pubmed-article:1859884 | pubmed:affiliation | Department of Laboratory Medicine/Pathology, University of Minnesota Medical School, Minneapolis. | lld:pubmed |
| pubmed-article:1859884 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1859884 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:1859884 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1859884 | lld:pubmed |
